Geist J R, Kafrawy A H, Shupe R E
Department of Oral Medicine/Periodontics, University of Detroit School of Dentistry, Mich.
Oral Surg Oral Med Oral Pathol. 1988 Jan;65(1):109-13. doi: 10.1016/0030-4220(88)90202-2.
This investigation monitored the effect of 2-mercaptopropionylglycine (MPG) in reducing radiation damage to the tooth-forming tissues. Fifty rats were exposed to x-ray doses of between 3 and 19 Gy directed toward the maxillary incisor germinal centers. Half of the animals were given an injection of MPG before irradiation, while the other rats were injected with saline solution. Administration of MPG did not significantly reduce the frequency of dentinal niche formation relative to the control teeth. The average lengths and percentage depths of the apicoincisal niches were statistically smaller in the groups treated with MPG. Although statistically significant, the mild protective effect of MPG was not clinically important because damage to the irradiated teeth was still extensive.
本研究监测了2-巯基丙酰甘氨酸（MPG）对减轻牙齿形成组织辐射损伤的作用。五十只大鼠接受了3至19 Gy的X射线照射，照射部位为上颌切牙生发中心。一半动物在照射前注射MPG，另一半大鼠注射生理盐水。与对照牙齿相比，MPG给药并未显著降低牙本质龛形成的频率。MPG治疗组的根尖切牙龛平均长度和深度百分比在统计学上较小。尽管具有统计学意义，但MPG的轻度保护作用在临床上并不重要，因为受照射牙齿的损伤仍然广泛。
