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颞叶癫痫患者头颅磁共振成像、脑电图异常与事件相关电位的相关性分析

[Correlation analysis about cranial magnetic resonance imaging and electroencephalogram abnormalities and event-related potentials in patients with temporal lobe epilepsy].

作者信息

Li T L, Xu H

机构信息

Department of Neurology, the First Affiliated Hospital of Kunming Medical University, Kunming 650032, China.

出版信息

Zhonghua Yi Xue Za Zhi. 2019 Jul 16;99(27):2115-2118. doi: 10.3760/cma.j.issn.0376-2491.2019.27.004.

Abstract

To investigate and evaluate the correlation between event-related potentials, cranial magnetic resonance imaging and electroencephalogram on cognitive function in patients with temporal lobe epilepsy. According to the exclusion criteria, 60 adult temporal lobe epilepsy patients (24 males and 36 females, 34±13 years old of average age) were enrolled in the First Affiliated Hospital of Kunming Medical University from March 2017 to September 2018. The magnetic resonance imaging (MRI), 24 h video electroencephalogram (EEG) and event-related potentials (ERPs) were detected in all patients, comparing the latency of N1, P2, N2, P3 waves and the amplitude of P3 waves. The mean latency of the waves of N1, P2, N2 and P3 and the mean amplitude of P3 wave were (108±25), (182±30), (256±33), (367±40) ms and (6.4±5.8) μV. There were significant differences in ERPs (latency of N1 wave, N2 wave and P3 wave) between the MRI abnormal group and the normal group (all 0.05). There was a statistically significant difference in the ERPs (P3 wave latency) between EEG examination found epileptiform or paroxysmal slow waves release group and the patients with EEG normality in the past 1 year (0.05) and the EEG test results were positively correlated with the latency of P2, N2 and P3 waves in ERPs, and negatively correlated with the amplitude of P3 waves (0.05). Patients with cognitive dysfunction in temporal lobe epilepsy are more likely to have abnormal MRI and EEG in the head. Both of them show different effects on the cognitive process of patients in ERPs.

摘要

探讨并评估事件相关电位、头颅磁共振成像及脑电图与颞叶癫痫患者认知功能之间的相关性。按照排除标准,选取2017年3月至2018年9月在昆明医科大学第一附属医院就诊的60例成年颞叶癫痫患者(男24例,女36例,平均年龄34±13岁)。对所有患者进行磁共振成像(MRI)、24小时视频脑电图(EEG)及事件相关电位(ERPs)检测,比较N1、P2、N2、P3波的潜伏期及P3波的波幅。N1、P2、N2、P3波的平均潜伏期及P3波的平均波幅分别为(108±25)、(182±30)、(256±33)、(367±40)ms和(6.4±5.8)μV。MRI异常组与正常组在ERPs(N1波、N2波和P3波潜伏期)方面存在显著差异(均P<0.05)。脑电图检查发现癫痫样或阵发性慢波发放组与过去1年脑电图正常患者在ERPs(P3波潜伏期)方面存在统计学差异(P<0.05),且脑电图检测结果与ERPs中P2、N2和P3波的潜伏期呈正相关,与P3波的波幅呈负相关(P<0.05)。颞叶癫痫伴认知功能障碍患者头部MRI及脑电图更易出现异常。二者在ERPs中对患者的认知过程均显示出不同影响。

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