抗高血压治疗对认知表现的年龄相关影响：是否能更好地预防老年痴呆症？
Age-Related Effect of Antihypertensive Treatment on Cognitive Performance: Is it Better Preventing Dementia in Older Age?
机构信息
Social Determinants of Health Research Centre, Medical School, Rafsanjan University, Rafsanjan, Iran.
Social Medicine Department, Medical School, Rafsanjan University, Rafsanjan, Iran.
出版信息
Am J Alzheimers Dis Other Demen. 2019 Nov-Dec;34(7-8):486-491. doi: 10.1177/1533317519859197. Epub 2019 Jul 17.
The aim of this study is to investigate the impact of optimal antihypertensive medication on cognitive function. In this 6-month clinical trial, 248 adults were randomly selected by a registry of hypertensive-treated patients (based on a National Hypertension Treatment Program), followed health centers located in Rafsanjan County, Southeast, Iran. Blood pressure was measured 3 times in each appointment pre- and posttreatment. Mini-Mental State Examination was used for cognitive performance evaluation. Paired test and multiple regression model showed significant correlation between "the differences of systolic and diastolic blood pressure levels" and "cognitive performance in treated patients more than 40 years old." Cognitive performance was not significantly different in patients less than 40 years old post antihypertensive treatment. Cognitive performance scores demonstrated significant increase in responders more than 40 years old post antihypertensive treatment. Antihypertensive treatment in responders with age equal or more than 40 years improves the level of cognitive performance significantly.
本研究旨在探讨最佳降压药物治疗对认知功能的影响。在这项为期 6 个月的临床试验中，通过高血压治疗患者的注册中心（基于国家高血压治疗计划），对 248 名成年人进行了随机选择，这些患者来自伊朗东南部拉夫桑詹县的健康中心。在每次就诊前和治疗后，血压测量了 3 次。采用简易精神状态检查评估认知功能表现。配对 t 检验和多元回归模型显示，“收缩压和舒张压水平的差异”与“40 岁以上治疗患者的认知表现”之间存在显著相关性。降压治疗后，40 岁以下患者的认知表现无显著差异。降压治疗后，40 岁以上的应答者认知表现评分显著增加。对于年龄等于或大于 40 岁的应答者，降压治疗可显著提高认知表现水平。
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