Xu Hangdi, Lou Wei, Fu Fangfang
1 Respiratory and Critical Care Medicine, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
2 Department of Respiratory Medicine, Zhuji People's Hospital, Zhuji, China.
J Int Med Res. 2019 Aug;47(8):3513-3521. doi: 10.1177/0300060519860684. Epub 2019 Jul 17.
Osteopontin (OPN) plays an important role in chronic airway remodeling and bronchial hyperresponsiveness. The association between OPN protein expression and asthma has been investigated extensively, but the results of these studies are inconsistent. The aim of this meta-analysis was to determine the relationship between OPN protein expression and asthma.
A systematic search was performed to identify published studies regarding the association between OPN protein expression and asthma. Studies with quantitative data were analyzed, and standardized mean differences were determined with 95% confidence intervals.
Nine studies were included in this analysis, involving 706 patients with asthma and 332 healthy controls. The pooled data from these studies demonstrated that OPN protein expression was significantly higher in patients with asthma than in controls. There was no significant difference in OPN protein between allergic asthma and nonallergic asthma. Moreover, there was no obvious relationship between OPN protein expression and the severity of asthma.
The results of this meta-analysis suggested that OPN protein expression is significantly upregulated in patients with asthma, but that it does not correlate with the type or severity of asthma.
骨桥蛋白（OPN）在慢性气道重塑和支气管高反应性中起重要作用。OPN蛋白表达与哮喘之间的关联已得到广泛研究，但这些研究结果并不一致。本荟萃分析的目的是确定OPN蛋白表达与哮喘之间的关系。
进行系统检索以识别已发表的关于OPN蛋白表达与哮喘关联的研究。对具有定量数据的研究进行分析，并确定标准化平均差及95%置信区间。
本分析纳入9项研究，涉及706例哮喘患者和332例健康对照。这些研究的汇总数据表明，哮喘患者的OPN蛋白表达显著高于对照组。过敏性哮喘和非过敏性哮喘之间的OPN蛋白无显著差异。此外，OPN蛋白表达与哮喘严重程度之间无明显关系。
本荟萃分析结果表明，哮喘患者的OPN蛋白表达显著上调，但与哮喘类型或严重程度无关。
