儿童听力损失的风险因素：系统文献综述和荟萃分析方案。
Risk factors for hearing loss in children: a systematic literature review and meta-analysis protocol.
机构信息
Faculty of Health Sciences, University of Ottawa, 451 Smyth Road, Ottawa, Ontario, K1H 8M5, Canada.
Child Hearing Laboratory, CHEO Research Institute, 401 Smyth Road, Ottawa, Ontario, K1H 8L1, Canada.
出版信息
Syst Rev. 2019 Jul 17;8(1):172. doi: 10.1186/s13643-019-1073-x.
BACKGROUND
Hearing loss in newborns and children is a public health concern, due to high prevalence and negative effects on their development. Early detection and intervention of childhood hearing loss may mitigate these negative effects. Population-based newborn hearing screening programs have been established worldwide to identify children at risk for congenital hearing loss and to follow children at risk for late onset or progressive hearing loss. This article presents the protocol for a systematic review that aims to review the risk factors associated with permanent hearing loss in children, including congenital, early, or late onset. Risk factors associated with progressive hearing loss will be investigated as a secondary aim.
METHODS
Scientific literature from the following databases will be investigated: MEDLINE, Ovid MEDLINE(R) Daily and Ovid MEDLINE(R), Embase, and CINAHL. The primary outcome is a permanent bilateral or unilateral hearing loss with congenital onset or onset during childhood (birth to 18 years). The secondary outcome is progressive hearing loss. Studies must report data on risk factors associated with permanent hearing loss; risk factors may be present at birth or later and result in immediate or delayed hearing loss. Randomized controlled trials, quasi-experimental studies, nonrandomized comparative and non-comparative studies, and case series will be included. The risk of bias will be assessed using the Qualitative Assessment Tool for Quantitative Studies (McMaster University). If aggregation of data is possible for a subsection of studies, we will pool data using meta-analysis techniques. If aggregation of data is not possible, a qualitative synthesis will be presented. We will assess the quality and strength of the overall body of evidence using the Grading of Recommendations Assessment, Development and Evaluation (GRADE). The systematic review follows the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) recommendations.
DISCUSSION
The resulting information will inform the update of a provincial audiological surveillance protocol for the Ontario Infant Hearing Program and will be applicable to early hearing detection and intervention (EHDI) programs worldwide.
SYSTEMATIC REVIEW REGISTRATION
We have registered the protocol in the International Prospective Register of Systematic Reviews (PROSPERO), registration number CRD42018104121.
背景
新生儿和儿童听力损失是一个公共卫生关注点，因为其发病率高，且对其发育有负面影响。早期发现和干预儿童听力损失可能减轻这些负面影响。全世界已建立了基于人群的新生儿听力筛查计划，以识别先天性听力损失风险儿童，并对有迟发性或进行性听力损失风险的儿童进行随访。本文介绍了一项系统评价的方案，旨在回顾与儿童永久性听力损失相关的危险因素，包括先天性、早期或迟发性听力损失。进行性听力损失的危险因素将作为次要目标进行调查。
方法
将从以下数据库调查科学文献：MEDLINE、Ovid MEDLINE(R) Daily 和 Ovid MEDLINE(R)、Embase 和 CINAHL。主要结局是先天性或儿童期（出生至 18 岁）起病的双侧或单侧永久性听力损失。次要结局是进行性听力损失。研究必须报告与永久性听力损失相关的危险因素数据；危险因素可能在出生时或之后存在，并导致即刻或延迟性听力损失。将纳入随机对照试验、准实验研究、非随机对照和非比较研究以及病例系列。使用 McMaster 大学的定量研究质量评估工具（Qualitative Assessment Tool for Quantitative Studies）评估偏倚风险。如果可以对部分研究进行数据汇总，我们将使用荟萃分析技术汇总数据。如果无法进行数据汇总，将呈现定性综合。我们将使用推荐评估、制定与评价（Grading of Recommendations Assessment, Development and Evaluation，GRADE）工具评估总体证据质量和强度。系统评价遵循系统评价和荟萃分析的首选报告项目（Preferred Reporting Items for Systematic Reviews and Meta-Analyses，PRISMA）建议。
讨论
所得信息将为安大略省婴儿听力计划的省级听力学监测方案更新提供信息，并将适用于全球的早期听力检测和干预（EHDI）计划。
系统评价注册
我们已在国际前瞻性系统评价注册库（PROSPERO）中注册了该方案，注册号为 CRD42018104121。
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