Keller C, Spengel F A
Medizinische Poliklinik, Universität München.
Klin Wochenschr. 1988 Feb 15;66(4):149-52. doi: 10.1007/BF01727783.
Three males, aged 15, 22, and 25 years, have been followed for Familial hypercholesterolemia (FH) from 1968 and 1976 onward, being treated by plasmapheresis for 2 to 5 years continuously, at 1- to 2-week intervals. Whereas two patients have been continuously treated to date, the third discontinued plasma exchange after 4 years and has been reevaluated 6 years later. Discontinuation of plasma exchange led to progression of atherosclerosis of the carotid arteries documented by duplex scan, whereas one patient exhibited marked regression of former impressive soft plaque-formation and one patient showed no significant change. Two-dimensional computer-analysis suggested a reduction of plaque mass of up to 45% in one patient.
三名男性，年龄分别为15岁、22岁和25岁，自1968年和1976年起因家族性高胆固醇血症（FH）接受随访，连续2至5年每隔1至2周接受一次血浆置换治疗。至今仍有两名患者持续接受治疗，第三名患者在4年后停止了血浆置换，并在6年后接受了重新评估。血浆置换的停止导致经双功扫描证实的颈动脉粥样硬化进展，而一名患者先前显著的软斑块形成明显消退，另一名患者则无显著变化。二维计算机分析表明，一名患者的斑块质量减少了高达45%。
