Thompson G R, Miller J P, Breslow J L
Br Med J (Clin Res Ed). 1985 Dec 14;291(6510):1671-3. doi: 10.1136/bmj.291.6510.1671.
Plasma exchange was undertaken in five patients with homozygous familial hypercholesterolaemia at intervals of two weeks for a mean of 8.4 years. These patients had survived an average of 5.5 years longer than their five respective homozygous siblings (p = 0.3), each of whom must have had a matching genetic defect but who died untreated. The 37% decrease in peak serum cholesterol concentrations maintained by plasma exchange presumably reduced progression of atherosclerosis in the treated patients and thus lessened their risk of premature death.
对五名纯合子家族性高胆固醇血症患者进行了血浆置换，每隔两周进行一次，平均持续8.4年。这些患者的存活时间比他们各自的五名纯合子兄弟姐妹平均长5.5年（p = 0.3），他们的兄弟姐妹都有匹配的基因缺陷，但未经治疗而死亡。血浆置换维持的血清胆固醇峰值浓度降低37%，可能减缓了接受治疗患者的动脉粥样硬化进展，从而降低了他们过早死亡的风险。
