Fei Xiang, Sheng Zhiyong, Yao Yongming
Trauma Research Center, Fourth Medical Center of the Chinese PLA General Hospital, Beijing 100048, China. Corresponding author: Yao Yongming, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Jun;31(6):772-776. doi: 10.3760/cma.j.issn.2095-4352.2019.06.022.
The tumor necrosis factor-α-induced protein 8-like (TNFAIP8, TIPE) family is recently identified proteins consisting of four highly homologous mammalian proteins: TIPE, TIPE1, TIPE2, and TIPE3. Although the four members share similar molecular structure and function, involving effects in pathophysiological processes of inflammation, immunity, tumors, stroke, angiogenesis, and other diseases, they have individual characteristics. Many studies have shown that TIPE2 is an essential negative regulator of both innate and adaptive immunity. Up-regulation of TIPE2 expression can alleviate excessive inflammation during septic shock and maintain hemostasis of macrophages, neutrophils, dendritic cells, T cells, and B cells. In this review, we summarize the current literature for structure feature, immune function, and regulatory mechanism of TIPE2, together with its clinical significance in the pathogenesis of immune disorders of a wide array of human diseases. Understanding the basic biology of this new molecule might help us to seek novel strategies for the immunomodulation of human diseases.
肿瘤坏死因子-α诱导蛋白8样（TNFAIP8，TIPE）家族是最近发现的由四种高度同源的哺乳动物蛋白组成的蛋白家族，即TIPE、TIPE1、TIPE2和TIPE3。尽管这四个成员具有相似的分子结构和功能，涉及炎症、免疫、肿瘤、中风、血管生成及其他疾病的病理生理过程，但它们也各有特点。许多研究表明，TIPE2是天然免疫和适应性免疫的重要负调节因子。TIPE2表达上调可减轻脓毒症休克期间的过度炎症反应，并维持巨噬细胞、中性粒细胞、树突状细胞、T细胞和B细胞的稳态。在本综述中，我们总结了目前关于TIPE2的结构特征、免疫功能、调节机制及其在多种人类疾病免疫紊乱发病机制中的临床意义的文献。了解这种新分子的基础生物学特性可能有助于我们寻找人类疾病免疫调节的新策略。
