肿瘤坏死因子α诱导蛋白8：炎症、免疫与人类疾病
TNFAIP8: Inflammation, Immunity and Human Diseases.
作者信息
Niture Suryakant, Moore John, Kumar Deepak
机构信息
Julius L. Chambers Biomedical Biotechnology Research Institute, North Carolina Central University Durham, NC 27707, USA.
出版信息
J Cell Immunol. 2019;1(2):29-34.
Abstract
Tumor necrosis factor (TNF)-alpha-induced protein 8 (TNFAIP8 /TIPE) family proteins are known to be involved in maintaining immune homeostasis. The TIPE family contains four members: tumor necrosis factor-α-induced protein 8 (TNFAIP8), TNFAIP8 like 1 (TIPE1), TNFAIP8 like 2 (TIPE2), and TNFAIP8 like 3 (TIPE3). Here we review the latest roles and associations of a founding member of TIPE family protein - TNFAIP8 in cellular function/signaling, inflammation, and immunity related human diseases.
摘要
已知肿瘤坏死因子（TNF）-α诱导蛋白8（TNFAIP8/TIPE）家族蛋白参与维持免疫稳态。TIPE家族包含四个成员：肿瘤坏死因子-α诱导蛋白8（TNFAIP8）、TNFAIP8样蛋白1（TIPE1）、TNFAIP8样蛋白2（TIPE2）和TNFAIP8样蛋白3（TIPE3）。在此，我们综述TIPE家族蛋白的创始成员——TNFAIP8在细胞功能/信号传导、炎症及免疫相关人类疾病中的最新作用及关联。
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