Liu Qingxiang, Xie Jianfeng, Yang Yi
Department of Critical Care Medicine, Zhongda Hospital, School of Medicine, Southeast University, Nanjing 210009, Jiangsu, China. Corresponding author: Yang Yi, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Jun;31(6):781-784. doi: 10.3760/cma.j.issn.2095-4352.2019.06.024.
Excessive or persistent inflammatory response is an important pathophysiological feature of sepsis, and the tissue damage and organ dysfunction caused by sepsis are related to the prognosis of patients. The cholinergic anti-inflammatory pathway releases acetylcholine (ACh) through the vaginal nerve and acts on the surface of the inflammatory cell α7 nicotine acetylcholine receptor (α7nAChR) to inhibit the production of inflammatory factors, so that the inflammatory response tends to be balanced. This article reviews the composition and effects of cholinergic anti-inflammatory pathways, the mechanism of regulating sepsis and its clinical application, in order to provide a new direction for the treatment of sepsis.
过度或持续的炎症反应是脓毒症的重要病理生理特征，脓毒症所致的组织损伤和器官功能障碍与患者预后相关。胆碱能抗炎通路通过迷走神经释放乙酰胆碱（ACh），作用于炎性细胞α7烟碱型乙酰胆碱受体（α7nAChR）表面，抑制炎性因子产生，使炎症反应趋于平衡。本文综述胆碱能抗炎通路的组成与作用、调控脓毒症的机制及其临床应用，以期为脓毒症的治疗提供新方向。
