mTOR信号通路在自闭症谱系障碍中作用的研究进展
[Research advances in the role of mTOR signaling pathway in autism spectrum disorder].
作者信息
Sheng Guo-Xia, Jiang Ke-Wen
机构信息
Department of Neurology, Children's Hospital of Zhejiang University, Hangzhou 310000, China.
出版信息
Zhongguo Dang Dai Er Ke Za Zhi. 2019 Jul;21(7):718-723. doi: 10.7499/j.issn.1008-8830.2019.07.019.
Abstract
Mammalian target of rapamycin (mTOR) is an intracellular signaling pathway molecule which regulates various fundamental physiological processes. The mTOR signaling pathway plays an important role in synaptic plasticity, information transmission and processing, and neuroregulation. Dysregulation of the mTOR signaling pathway is generally considered to be related to the pathogenesis of autism spectrum disorder (ASD); meanwhile, the mTOR inhibitor can ameliorate the symptoms of ASD. The role of mTOR in the pathogenesis of ASD is summarized in this article to provide a theoretical basis for targeted therapy of ASD.
摘要
雷帕霉素哺乳动物靶点（mTOR）是一种调节各种基本生理过程的细胞内信号通路分子。mTOR信号通路在突触可塑性、信息传递与处理以及神经调节中发挥着重要作用。mTOR信号通路失调通常被认为与自闭症谱系障碍（ASD）的发病机制有关；同时，mTOR抑制剂可改善ASD的症状。本文总结了mTOR在ASD发病机制中的作用，为ASD的靶向治疗提供理论依据。
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