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补充色氨酸对负反馈敏感性和逆向学习的不同影响。

Dissociable Effects of Tryptophan Supplementation on Negative Feedback Sensitivity and Reversal Learning.

作者信息

Thirkettle Martin, Barker Laura-Marie, Gallagher Thomas, Nayeb Nazgol, Aquili Luca

机构信息

Department of Psychology, Sociology and Politics, Sheffield Hallam University, Sheffield, United Kingdom.

出版信息

Front Behav Neurosci. 2019 Jun 28;13:127. doi: 10.3389/fnbeh.2019.00127. eCollection 2019.

DOI:10.3389/fnbeh.2019.00127
PMID:31316358
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6609902/
Abstract

Serotonin has been shown to modulate probabilistic reversal learning (PRL) and negative feedback sensitivity (NFS) in both animal and human studies. Whilst these two measures are tightly coupled, some studies have suggested that these may be mediated by independent mechanisms; the former, representing perseveration and cognitive flexibility, and the latter measuring the ability to maintain a response set (win-stay) at the expense of lose-shift behavior when occasional misleading feedback has been presented. Here, we tested this hypothesis in 44 healthy participants who were administered tryptophan (22 placebo, 22 tryptophan), a precursor to serotonin. We found a dissociable effect of tryptophan supplementation on PRL/NFS. Specifically, tryptophan administration increased NFS compared to the placebo group but had no effect on PRL. We discuss these findings in relation to dosages and with a particular focus on the acute tryptophan depletion (ATD) procedures.

摘要

在动物和人类研究中，血清素已被证明可调节概率反转学习（PRL）和负反馈敏感性（NFS）。虽然这两种测量方法紧密相关，但一些研究表明，它们可能由独立的机制介导；前者代表固执和认知灵活性，后者测量在偶尔出现误导性反馈时，以牺牲“输-转换”行为为代价维持反应集（赢-留）的能力。在此，我们对44名健康参与者进行了测试，这些参与者被给予血清素的前体色氨酸（22名服用安慰剂，22名服用色氨酸）。我们发现补充色氨酸对PRL/NFS有可分离的影响。具体而言，与安慰剂组相比，服用色氨酸可提高NFS，但对PRL没有影响。我们将结合剂量讨论这些发现，并特别关注急性色氨酸耗竭（ATD）程序。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/a64d9ffc1ee8/fnbeh-13-00127-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/8f5d04fa176d/fnbeh-13-00127-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/ab76022016b6/fnbeh-13-00127-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/a64d9ffc1ee8/fnbeh-13-00127-g0003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/8f5d04fa176d/fnbeh-13-00127-g0001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/ab76022016b6/fnbeh-13-00127-g0002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ed2d/6609902/a64d9ffc1ee8/fnbeh-13-00127-g0003.jpg

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