Conway Fiona, Brown Alan S
New York State Psychiatric Institute, Columbia University Medical Center, New York, NY, United States.
Front Psychiatry. 2019 Jun 28;10:430. doi: 10.3389/fpsyt.2019.00430. eCollection 2019.
Maternal immune activation (MIA) at the time of gestation has been linked to increased risk of neurodevelopmental psychiatric disorders. Animal and human models have been used to evaluate the relationship between MIA and these outcomes. Given that each of these two disciplines of study have their benefits and limitations, a translational perspective is expected to illuminate more than by the use of any single approach. In this article, we discuss this translational framework and explore how it may be enhanced by the utilization of epigenetic studies and by investigating the microbiome. In this perspectives piece, we focus on the impact of epidemiologic studies, animal models, and preclinical studies in the literature on MIA as well as the potential for greater integration between fields.
孕期母体免疫激活（MIA）与神经发育性精神障碍风险增加有关。动物模型和人体模型已被用于评估MIA与这些结果之间的关系。鉴于这两个研究领域各有其优缺点，从转化医学的角度进行研究有望比使用任何单一方法获得更多的启示。在本文中，我们将讨论这一转化医学框架，并探讨如何通过表观遗传学研究和微生物组研究来加强这一框架。在这篇观点文章中，我们重点关注了文献中关于MIA的流行病学研究、动物模型和临床前研究的影响，以及各领域之间加强整合的潜力。
