Li Qi, Liu Sha, Guo Meng, Yang Cheng-Xiang, Xu Yong
Department of Psychiatry, First Hospital/First Clinical Medical College of Shanxi Medical University, Taiyuan, China.
MDT Center for Cognitive Impairment and Sleep Disorders, First Hospital of Shanxi Medical University, Taiyuan, China.
Front Neurol. 2019 Jun 27;10:688. doi: 10.3389/fneur.2019.00688. eCollection 2019.
Electroconvulsive therapy (ECT) was established based on Meduna's hypothesis that there is an antagonism between schizophrenia and epilepsy, and that the induction of a seizure could alleviate the symptoms of schizophrenia. However, subsequent investigations of the mechanisms of ECT have largely ignored this originally established relationship between these two disorders. With the development of functional magnetic resonance imaging (fMRI), brain-network studies have demonstrated that schizophrenia and epilepsy share common dysfunctions in the default-mode network (DMN), saliency network (SN), dorsal-attention network (DAN), and central-executive network (CEN). Additionally, fMRI-defined brain networks have also been shown to be useful in the evaluation of the treatment efficacy of ECT. Here, we compared the ECT-induced changes in the pathological conditions between schizophrenia and epilepsy in order to offer further insight as to whether the mechanisms of ECT are truly based on antagonistic and/or affinitive relationships between these two disorders.
电休克疗法（ECT）是基于梅杜纳的假说建立的，该假说认为精神分裂症和癫痫之间存在拮抗作用，诱发癫痫发作可以缓解精神分裂症的症状。然而，随后对ECT机制的研究在很大程度上忽略了这两种疾病最初确立的关系。随着功能磁共振成像（fMRI）的发展，脑网络研究表明，精神分裂症和癫痫在默认模式网络（DMN）、突显网络（SN）、背侧注意网络（DAN）和中央执行网络（CEN）中存在共同的功能障碍。此外，功能磁共振成像定义的脑网络也已被证明可用于评估ECT的治疗效果。在这里，我们比较了ECT引起的精神分裂症和癫痫病理状况的变化，以便进一步了解ECT的机制是否真的基于这两种疾病之间的拮抗和/或亲和关系。
