Akbari Nayereh, Hormati Ahmad, Sharifipour Ehsan, Hejazi Seyed Amir, Jafari Fatemeh, Mousavi-Aghdas Seyed Ali, Golzari Samad Ej
Neuroscience Research Center, Qom University of Medical Sciences, Qom, Iran.
Gastroenterology and Hepatology Research Center, Qom University of Medical Sciences, Qom, Iran.
Iran J Neurol. 2019 Jan 5;18(1):19-24.
Numerous studies have evaluated the impact of Helicobacter pylori (H. pylori) eradication on the number, severity, and recurrence of migraine attacks. But the association of migraine, H. pylori, and gastrointestinal (GI) presentation is challenging. The aim of the current study was to investigate the correlation between migraine, H. pylori, and peptic ulcers among patients with dyspepsia undergoing upper GI endoscopy. 305 patients with dyspepsia referring to our endoscopy ward, Shahid Beheshti Hospital affiliated to Qom University of Medical Sciences, Qom, Iran, for upper GI endoscopy filled out the study questionnaire. If a patient was experiencing headaches and the migraine was confirmed by neurologists, he/she was asked to answer the questions related to migraine, which were prepared exactly from Migraine Disability Assessment (MIDAS) questionnaire. The relation between migraine and confirmed H. pylori contamination was investigated using statistical models. Of all the 305 patients, 133 (43.6%) had confirmed episodic migraine headaches (MHs) and 177 patients (58.04%) had positive RUT for confirming H. pylori contamination, of which 123 (69.5%) had confirmed migraine. 52 (17.0%) had duodenal peptic ulcer(s), of which, 49 (94.2%) had a positive rapid urease test (RUT) (P < 0.001). 20 (6.5%) of all patients had the gastric peptic ulcer(s) which did not have a significant relation with H. pylori contamination. There was a significant relationship between the peptic ulcer site and migraine. In total, 177 patients (58.0%) had a positive RUT. History of migraine was significantly positive in those with positive H. Pylori contamination. Notably, multivariable analysis demonstrated a significant relation of H. pylori and migraine at younger ages. The prevalence of H. pylori and migraine in patients with dyspepsia seems to be high. Moreover, there is a meaningful association between migraine, duodenal peptic ulcers, and H. pylori infection, too.
众多研究评估了根除幽门螺杆菌（H. pylori）对偏头痛发作的次数、严重程度及复发情况的影响。但偏头痛、幽门螺杆菌与胃肠道表现之间的关联颇具挑战性。本研究旨在调查接受上消化道内镜检查的消化不良患者中偏头痛、幽门螺杆菌与消化性溃疡之间的相关性。305名因上消化道内镜检查转诊至伊朗库姆医科大学附属沙希德·贝赫什提医院内镜病房的消化不良患者填写了研究问卷。若患者正在经历头痛且经神经科医生确诊为偏头痛，则要求其回答与偏头痛相关的问题，这些问题完全取自偏头痛残疾评估（MIDAS）问卷。使用统计模型研究偏头痛与确诊的幽门螺杆菌感染之间的关系。在所有305名患者中，133名（43.6%）确诊患有发作性偏头痛（MHs），177名患者（58.04%）尿素酶试验（RUT）呈阳性以确诊幽门螺杆菌感染，其中123名（69.5%）确诊患有偏头痛。52名（17.0%）患有十二指肠消化性溃疡，其中49名（94.2%）快速尿素酶试验（RUT）呈阳性（P<0.001）。所有患者中有20名（6.5%）患有胃溃疡，其与幽门螺杆菌感染无显著关系。消化性溃疡部位与偏头痛之间存在显著关系。总共有177名患者（58.0%）RUT呈阳性。幽门螺杆菌感染阳性者偏头痛病史显著呈阳性。值得注意的是，多变量分析表明幽门螺杆菌与年轻时的偏头痛存在显著关系。消化不良患者中幽门螺杆菌和偏头痛的患病率似乎较高。此外，偏头痛、十二指肠消化性溃疡与幽门螺杆菌感染之间也存在有意义的关联。
