一种可通过逐步微环境刺激激活的基于 PEGylated megamer 的 microRNA 递药系统。
A PEGylated megamer-based microRNA delivery system activatable by stepwise microenvironment stimulation.
机构信息
Department of Hepatobiliary and Pancreatic Surgery, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China.
Institute of Chemical Biology and Pharmaceutical Chemistry, Zhejiang University, Hangzhou 310028, China.
出版信息
Chem Commun (Camb). 2019 Aug 14;55(63):9363-9366. doi: 10.1039/c9cc03846a. Epub 2019 Jul 18.
We developed a biodegradable, oncosensitive, megamer-based delivery system for miRNA therapy. The miRNA nanotherapeutics, activatable by stepwise stimulation of acidity and reduction mimicking tumor microenvironment, efficiently improve liver-specific miR-122 expression, increasing the possibility of translational application of miR-122 therapy against liver cancer.
我们开发了一种基于生物可降解、肿瘤敏感的巨分子的 miRNA 治疗递药系统。这种 miRNA 纳米疗法可通过逐步模拟肿瘤微环境的酸化和还原刺激来激活，能有效提高肝脏特异性 miR-122 的表达，增加 miR-122 治疗肝癌的转化应用的可能性。
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