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Behçet's syndrome: focus on pathogenetic background, clinical phenotypes and specific treatments.

作者信息

Emmi Giacomo, Prisco Domenico

机构信息

Department of Experimental and Clinical Medicine, University of Firenze, Largo Brambilla 3, 50134, Florence, Italy.

出版信息

Intern Emerg Med. 2019 Aug;14(5):639-643. doi: 10.1007/s11739-019-02154-9. Epub 2019 Jul 17.

DOI:10.1007/s11739-019-02154-9
PMID:31317313
Abstract
摘要

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Behçet's syndrome: focus on pathogenetic background, clinical phenotypes and specific treatments.白塞病：聚焦发病机制背景、临床表型及特异性治疗
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2
A single endoplasmic reticulum aminopeptidase-1 protein allotype is a strong risk factor for Behçet's disease in HLA-B*51 carriers.单一内质网氨肽酶-1蛋白同种异型是HLA-B*51携带者患白塞病的一个强风险因素。
Ann Rheum Dis. 2016 Dec;75(12):2208-2211. doi: 10.1136/annrheumdis-2015-209059. Epub 2016 May 23.
3
The association of Behçet's syndrome with HLA-B51 as understood in 2021.2021 年对 Behçet 综合征与 HLA-B51 关联性的认识。
Curr Opin Rheumatol. 2022 Jan 1;34(1):4-9. doi: 10.1097/BOR.0000000000000846.
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Genetics of Behçet's disease: lessons learned from genomewide association studies.贝切特病的遗传学研究：全基因组关联研究的启示。
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[Pathogenic concepts, nosological limits and diagnostic criteria of Behçet's disease].[白塞病的发病机制、疾病分类界限及诊断标准]
J Mal Vasc. 1988;13(3):250-6.
6
Genome-wide association analysis identifies new susceptibility loci for Behçet's disease and epistasis between HLA-B*51 and ERAP1.全基因组关联分析鉴定出白塞病的新易感位点和 HLA-B*51 与 ERAP1 之间的上位性。
Nat Genet. 2013 Feb;45(2):202-7. doi: 10.1038/ng.2520. Epub 2013 Jan 6.
7
Genetic and environmental factors in the development of Behcet's disease.白塞病发病中的遗传和环境因素
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A genetic study of Behçet's disease in Taiwan Chinese.台湾华裔人群中白塞病的遗传学研究。
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[Behçet's disease].[白塞病]
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HLA antigens in a family with Behçet's syndrome.白塞病家族中的人类白细胞抗原（HLA）抗原
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Lower total cholesterol and HDL-C levels are associated with increased risk of Behçet's disease in a prospective nationwide Korean study.在一项韩国全国性前瞻性研究中，总胆固醇和高密度脂蛋白胆固醇水平较低与白塞病风险增加相关。
Sci Rep. 2025 May 1;15(1):15272. doi: 10.1038/s41598-025-99179-2.
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Oral Health and Its Aetiological Role in Behçet's Disease.口腔健康及其在白塞病中的病因学作用。
Front Med (Lausanne). 2021 May 20;8:613419. doi: 10.3389/fmed.2021.613419. eCollection 2021.
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Treatment of Behçet's Disease: An Algorithmic Multidisciplinary Approach.

本文引用的文献

1
The Results of Interferon-Alpha Treatment in Behçet Uveitis.《干扰素-α 在 Behçet 葡萄膜炎治疗中的结果》。
Ocul Immunol Inflamm. 2020 Apr 2;28(3):498-504. doi: 10.1080/09273948.2019.1587473. Epub 2019 Jun 4.
2
Adalimumab Accounts for Long-Term Control of Noninfectious Uveitis Also in the Absence of Concomitant DMARD Treatment: A Multicenter Retrospective Study.阿达木单抗在无伴随 DMARD 治疗的情况下也可长期控制非感染性葡萄膜炎：一项多中心回顾性研究。
Mediators Inflamm. 2019 Feb 10;2019:1623847. doi: 10.1155/2019/1623847. eCollection 2019.
3
Distribution of rs17482078 and rs27044 ERAP1 polymorphisms in a group of Italian Behçet's syndrome patients: a preliminary case-control study.
白塞病的治疗：一种多学科算法治疗方法。
Front Med (Lausanne). 2021 Apr 28;8:624795. doi: 10.3389/fmed.2021.624795. eCollection 2021.
4
Optic neuritis as a presenting feature of Behçet's disease: case-based review.以病例为基础的视神经炎作为贝赫切特病的首发表现。
Rheumatol Int. 2021 Jan;41(1):189-195. doi: 10.1007/s00296-020-04690-6. Epub 2020 Aug 29.
5
Behçet's syndrome in Italy: a detailed retrospective analysis of 396 cases seen in 3 tertiary referral clinics.意大利的白塞综合征：3 家三级转诊诊所观察到的 396 例详细回顾性分析。
Intern Emerg Med. 2020 Sep;15(6):1031-1039. doi: 10.1007/s11739-019-02248-4. Epub 2020 Feb 1.
rs17482078 和 rs27044 ERAP1 多态性在意大利一组 Behçet 综合征患者中的分布：一项初步的病例对照研究。
Intern Emerg Med. 2019 Aug;14(5):713-718. doi: 10.1007/s11739-019-02056-w. Epub 2019 Feb 28.
4
The right place of interleukin-1 inhibitors in the treatment of Behçet's syndrome: a systematic review.白塞氏综合征治疗中白细胞介素-1 抑制剂的恰当位置：系统评价。
Rheumatol Int. 2019 Jun;39(6):971-990. doi: 10.1007/s00296-019-04259-y. Epub 2019 Feb 25.
5
Phenotypes in Behçet's syndrome.贝切特综合征的表型。
Intern Emerg Med. 2019 Aug;14(5):677-689. doi: 10.1007/s11739-019-02046-y. Epub 2019 Feb 11.
6
Pathergy testing: prospective comparison of dermatoscopic evaluation and naked eye examination.皮肤划痕试验：皮肤镜评估与肉眼检查的前瞻性比较。
Intern Emerg Med. 2019 Aug;14(5):699-703. doi: 10.1007/s11739-019-02039-x. Epub 2019 Feb 8.
7
Efficacy of anti-tumour necrosis factor-α monoclonal antibodies in patients with non-infectious anterior uveitis.抗肿瘤坏死因子-α 单克隆抗体治疗非感染性前葡萄膜炎的疗效。
Clin Exp Rheumatol. 2019 Mar-Apr;37(2):301-305. Epub 2019 Jan 18.
8
Assessment of deep venous thrombosis in the lower extremity in Behçet's syndrome: MR venography versus Doppler ultrasonography.评估 Behçet 综合征下肢深静脉血栓形成：MR 静脉造影与多普勒超声检查。
Intern Emerg Med. 2019 Aug;14(5):705-711. doi: 10.1007/s11739-019-02040-4. Epub 2019 Feb 2.
9
Update on the treatment of Behçet's syndrome.关于白塞综合征治疗的最新进展。
Intern Emerg Med. 2019 Aug;14(5):661-675. doi: 10.1007/s11739-019-02035-1. Epub 2019 Jan 25.
10
Triggering agents and microbiome as environmental factors on Behçet's syndrome.触发因素和微生物组作为环境因素对贝赫切特综合征的影响。
Intern Emerg Med. 2019 Aug;14(5):653-660. doi: 10.1007/s11739-018-2000-1. Epub 2018 Dec 6.