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白塞病发病中的遗传和环境因素

Genetic and environmental factors in the development of Behcet's disease.

作者信息

Tanaka K, Kajiyama K, Imamura T, Jimi S, Watanabe T, Sato H, Okochi K, Inoue T

出版信息

Tohoku J Exp Med. 1985 Feb;145(2):205-13. doi: 10.1620/tjem.145.205.

DOI:10.1620/tjem.145.205
PMID:3857725
Abstract

Analysis of HLA antigens and case control study were performed in 50 patients with Behcet's disease. Frequency of HLA-Bw51 was significantly increased in the patients (52.0%) as compared to that in the control subjects (16.0%). In case control study, the incidence of tonsillitis, and use of public bath and a privy were more frequently seen in the patients than in the controls. The patients were frequently exposed to agricultural chemicals before onset of the disease. Daily ingestion of vegetable salad and milk was less frequent in the patients than in the controls. Heterogeneity of Behcet's disease and results of multivariate analysis for selected variables were discussed.

摘要

对50例白塞病患者进行了HLA抗原分析和病例对照研究。与对照组(16.0%)相比,患者中HLA - Bw51的频率显著增加(52.0%)。在病例对照研究中,患者扁桃体炎的发病率、使用公共浴室和厕所的情况比对照组更常见。患者在疾病发作前经常接触农用化学品。患者每日食用蔬菜沙拉和牛奶的频率低于对照组。讨论了白塞病的异质性以及所选变量的多因素分析结果。

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Genetic and environmental factors in the development of Behcet's disease.白塞病发病中的遗传和环境因素
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2
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引用本文的文献

1
HLA-B51/B5 and the risk of Behçet's disease: a systematic review and meta-analysis of case-control genetic association studies.HLA - B51/B5与白塞病风险:病例对照基因关联研究的系统评价和荟萃分析
Arthritis Rheum. 2009 Oct 15;61(10):1287-96. doi: 10.1002/art.24642.
2
Is Behçet's disease triggered by childhood infection?白塞病是由儿童期感染引发的吗?
Ann Rheum Dis. 1989 May;48(5):421-3. doi: 10.1136/ard.48.5.421.