Dor C, Gajanayake I, Kortum A, Day M J, Tappin S, Harris B, Battersby I, Walker D, Glanemann B, Myatt P, Dunning M, Bexfield N
Department of Veterinary Medicine and Science, University of Nottingham, Nottingham, NG7 2RD, UK.
Willows Veterinary Centre and Referral Service, Solihull, West Midlands, B90 4NH, UK.
J Small Anim Pract. 2019 Sep;60(9):551-558. doi: 10.1111/jsap.13052. Epub 2019 Jul 17.
To describe the history, clinicopathological abnormalities, diagnostic imaging findings, lymph node cytological/histological appearance, treatment and outcome of English springer spaniels diagnosed with idiopathic pyogranulomatous lymphadenitis.
In this retrospective UK-based multicentre study, 64 dogs were recruited from 10 referral centres, 32 first-opinion practices and three histopathology/cytology laboratories, between 2010 and 2016.
The median age at presentation was 6 years (range: 0.17 to 11.75). Neutered females were frequently affected. Pyrexia (83.8%), peripheral lymphadenomegaly (78.4%), dermatological lesions (72.9%), lethargy (67.6%), hyporexia (54%), diarrhoea (29.7%), coughing (24.3%), epistaxis, sneezing or nasal discharge (21.6%), ocular signs (21.6%) and vomiting (16.2%) were reported in dogs for which the history and physical examination records were available. Popliteal (45.3%), superficial cervical (35.9%) and submandibular (37.5%) lymphadenomegaly were frequently reported. Haematology and serum biochemistry revealed non-specific changes. When undertaken, testing for infectious diseases was negative in all cases. Lymph node cytology, histopathology or both demonstrated mixed inflammatory (27%), pyogranulomatous (24%), neutrophilic (20%) or granulomatous (11%) lymphadenitis. Treatment details were available for 38 dogs, with 34 receiving prednisolone for a median duration of 15 weeks (range: 1 to 28 weeks). A good to excellent clinical response was reported in all but one case. Ten dogs relapsed after discontinuing prednisolone.
Idiopathic pyogranulomatous lymphadenitis should be considered as a differential diagnosis for lymphadenopathy and pyrexia in English springer spaniels. The characteristics of the disease, absence of identifiable infectious aetiology and response to glucocorticoid therapy suggest an immune-mediated aetiology.
描述被诊断为特发性脓性肉芽肿性淋巴结炎的英国激飞猎犬的病史、临床病理异常、诊断性影像学表现、淋巴结细胞学/组织学特征、治疗及预后情况。
在这项基于英国的回顾性多中心研究中，2010年至2016年间从10个转诊中心、32个初诊机构以及3个组织病理学/细胞学实验室招募了64只犬。
就诊时的中位年龄为6岁（范围：0.17至11.75岁）。绝育雌性犬常受影响。对于有病史和体格检查记录的犬，报告有发热（83.8%）、外周淋巴结肿大（78.4%）、皮肤病变（72.9%）、嗜睡（67.6%）、食欲减退（54%）、腹泻（29.7%）、咳嗽（24.3%）、鼻出血、打喷嚏或鼻分泌物（21.6%）、眼部症状（21.6%）以及呕吐（16.2%）。常报告有腘淋巴结肿大（45.3%）、颈浅淋巴结肿大（35.9%）和下颌下淋巴结肿大（37.5%）。血液学和血清生化检查显示非特异性变化。进行传染病检测时，所有病例结果均为阴性。淋巴结细胞学检查、组织病理学检查或两者均显示为混合性炎症（27%）、脓性肉芽肿性（24%）、嗜中性粒细胞性（20%）或肉芽肿性（11%）淋巴结炎。有38只犬的治疗细节可用，其中34只接受泼尼松龙治疗，中位疗程为15周（范围：1至28周）。除1例病例外，所有病例均报告有良好至优秀的临床反应。10只犬在停用泼尼松龙后复发。
特发性脓性肉芽肿性淋巴结炎应被视为英国激飞猎犬淋巴结病和发热的鉴别诊断之一。该疾病的特征、无明确的感染病因以及对糖皮质激素治疗的反应提示其病因可能为免疫介导。
