Schmiegel W H, Caesar J, Kalthoff H, Greten H, Schreiber H W, Thiele H G
Medizinische und Chirurgische Universitätsklinik, Hamburg, Federal Republic of Germany.
Pancreas. 1988;3(2):180-8. doi: 10.1097/00006676-198804000-00012.
Modulation of the growth of human pancreatic cancer cell lines in vitro by recombinant human tumor necrosis factor-alpha (TNF-alpha) and recombinant human interferon-gamma (IFN-gamma) was investigated. TNF-alpha exerted antiproliferative effects on three of nine pancreatic cancer cell lines and WiDR colorectal cancer cells. When administered together with IFN-gamma TNF-alpha showed enhanced antiproliferative effects on a subset of the pancreatic cancer cell lines tested, including those found to be insensitive to treatment with TNF-alpha alone. Thus the antiproliferative effect achieved by a combined treatment with TNF-alpha and IFN-gamma exceeded that observed with either drug alone in seven of nine pancreatic cancer cell lines.
研究了重组人肿瘤坏死因子-α（TNF-α）和重组人干扰素-γ（IFN-γ）对人胰腺癌细胞系体外生长的调节作用。TNF-α对9种胰腺癌细胞系中的3种以及WiDR结肠癌细胞具有抗增殖作用。当与IFN-γ联合使用时，TNF-α对部分受试胰腺癌细胞系显示出增强的抗增殖作用，包括那些对单独使用TNF-α治疗不敏感的细胞系。因此，在9种胰腺癌细胞系中的7种中，TNF-α和IFN-γ联合治疗所产生的抗增殖作用超过了单独使用任何一种药物时所观察到的效果。
