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Photophobe (Ppb), a Drosophila mutant with a reversed sign of phototaxis; the mutation shows an allele-specific interaction with sevenless.畏光（Ppb），一种具有反向趋光性的果蝇突变体；该突变与sev（sevenless）表现出等位基因特异性相互作用。
Proc Natl Acad Sci U S A. 1988 Jun;85(11):3960-4. doi: 10.1073/pnas.85.11.3960.
2
Isolation of temperature-sensitive mutations of the tyrosine kinase receptor sevenless (sev) in Drosophila and their use in determining its time of action.果蝇中酪氨酸激酶受体sevenless（sev）温度敏感突变体的分离及其在确定其作用时间方面的应用。
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3
[Phototaxis and adaptation of the eyeless Drosophila melanogaster line].[无眼黑腹果蝇品系的趋光性与适应性]
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4
The interaction of bride of sevenless with sevenless is conserved between Drosophila virilis and Drosophila melanogaster.无七之妻与无七的相互作用在粗壮果蝇和黑腹果蝇之间是保守的。
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Molecular characterization and expression of sevenless, a gene involved in neuronal pattern formation in the Drosophila eye.
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6
Phototactic and geotactic behavior of countercurrent defective mutants of Drosophila melanogaster.黑腹果蝇逆流缺陷突变体的趋光性和趋地性行为
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The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7.无七蛋白在发育中的果蝇视网膜细胞膜顶端表达；它并不局限于R7细胞。
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Hypomorphic mutations in the larval photokinesis A (lphA) gene have stage-specific effects on visual system function in Drosophila melanogaster.幼虫光运动A（lphA）基因中的亚效突变对黑腹果蝇视觉系统功能具有阶段特异性影响。
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Social attraction in Drosophila is regulated by the mushroom body and serotonergic system.果蝇的社交吸引力受蘑菇体和血清素能系统的调节。
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Positive and negative signaling mechanisms in the regulation of photoreceptor induction in the developing Drosophila retina. Review.果蝇发育视网膜中光感受器诱导调控的正负信号机制。综述。
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Sevenless: a cell-specific homeotic mutation of the Drosophila eye.七体（Sevenless）：果蝇眼的一种细胞特异性同源突变。
Science. 1986 Jan 24;231(4736):400-2. doi: 10.1126/science.231.4736.400.
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Genetic dissection of the photoreceptor system in the compound eye of Drosophila melanogaster.黑腹果蝇复眼中光感受器系统的遗传学剖析。
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Structural brain mutant of Drosophila melanogaster with reduced cell number in the medulla cortex and with normal optomotor yaw response.果蝇中脑皮质细胞数量减少的结构脑突变体，其光转导偏航反应正常。
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BEHAVIORAL MUTANTS OF Drosophila ISOLATED BY COUNTERCURRENT DISTRIBUTION.通过逆流分配法分离得到的果蝇行为突变体。
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Genetics of the nervous system in Drosophila.果蝇神经系统的遗传学
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Abnormal electroretinograms in visual mutants of Drosophila.果蝇视觉突变体中的异常视网膜电图。
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Nonphototactic mutants in a study of vision of Drosophila.果蝇视觉研究中的非趋光性突变体。
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Conditioned behavior in Drosophila melanogaster.黑腹果蝇的条件行为。
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Drosophila mushroom body mutants are deficient in olfactory learning.果蝇蘑菇体突变体在嗅觉学习方面存在缺陷。
J Neurogenet. 1985 Feb;2(1):1-30. doi: 10.3109/01677068509100140.
10
The sevenless+ protein is expressed apically in cell membranes of developing Drosophila retina; it is not restricted to cell R7.无七蛋白在发育中的果蝇视网膜细胞膜顶端表达；它并不局限于R7细胞。
Cell. 1987 Oct 9;51(1):151-8. doi: 10.1016/0092-8674(87)90020-1.

畏光（Ppb），一种具有反向趋光性的果蝇突变体；该突变与sev（sevenless）表现出等位基因特异性相互作用。

Photophobe (Ppb), a Drosophila mutant with a reversed sign of phototaxis; the mutation shows an allele-specific interaction with sevenless.

作者信息

Ballinger D G, Benzer S

机构信息

Division of Biology, California Institute of Technology, Pasadena 91125.

出版信息

Proc Natl Acad Sci U S A. 1988 Jun;85(11):3960-4. doi: 10.1073/pnas.85.11.3960.

DOI:10.1073/pnas.85.11.3960
PMID:3131766
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC280340/
Abstract

We have isolated a dominant behavioral mutation, Photophobe (Ppb), on the second chromosome of Drosophila melanogaster. Although wild-type flies are attracted towards green light, flies homozygous for the Ppb mutation avoid it over an intensity range of six logarithms. Ppb interacts in a dominant way with mutations in the sevenless (sev) gene, an X-chromosomal gene necessary for photoreceptor cell 7 differentiation in the Drosophila retina. Specific alleles of sev alter the Ppb behavioral phenotype; of eight sev alleles tested, two alleles enhanced the negative phototaxis of Ppb, whereas six alleles had the opposite effect. In no mutant combination of Ppb and sev was photoreceptor cell 7 restored. These data show that the sev gene, in addition to its role in the differentiation of photoreceptor cell 7, plays a role along with Ppb in a common visual information-processing pathway.

摘要

我们在黑腹果蝇的第二条染色体上分离出了一个显性行为突变体，畏光（Ppb）。野生型果蝇会被绿光吸引，而Ppb突变体的纯合子果蝇在六个对数强度范围内都会避开绿光。Ppb与七无（sev）基因的突变以显性方式相互作用，sev基因是果蝇视网膜中光感受器细胞7分化所必需的X染色体基因。sev的特定等位基因会改变Ppb的行为表型；在测试的八个sev等位基因中，两个等位基因增强了Ppb的负趋光性，而六个等位基因则有相反的作用。在Ppb和sev的任何突变组合中，光感受器细胞7都没有恢复。这些数据表明，sev基因除了在光感受器细胞7的分化中起作用外，还与Ppb在共同的视觉信息处理途径中发挥作用。