一项关于跑步训练对 MS 患者视空间记忆影响的初步研究：海马体在默认模式网络中的功能嵌入是否更强？
A pilot study of the effects of running training on visuospatial memory in MS: A stronger functional embedding of the hippocampus in the default-mode network?
机构信息
Department of Anatomy & Neurosciences, MS Center Amsterdam, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands.
REVAL Rehabilitation Research Center, BIOMED, Faculty of Rehabilitation Sciences, Hasselt University, Hasselt, Belgium; Institute of Psychoacoustics and Electronic Music (IPEM), Faculty of Arts and Philosophy, Gent University, Gent, Belgium.
出版信息
Mult Scler. 2020 Oct;26(12):1594-1598. doi: 10.1177/1352458519863644. Epub 2019 Jul 18.
BACKGROUND/OBJECTIVE: Endurance exercise can improve memory function in persons with multiple sclerosis (pwMS), but the effects on hippocampal functioning are currently unknown. We investigated the effects of a running intervention on memory and hippocampal functional connectivity in pwMS.
METHODS/RESULTS: Memory and resting-state functional magnetic resonance imaging (fMRI) data were collected in a running intervention ( = 15) and waitlist group ( = 14). Visuospatial memory improvement was correlated to increased connectivity between the hippocampus and the default-mode network (DMN) in the intervention group only.
CONCLUSION
As a result of endurance exercise, improvements in visuospatial memory may be mediated by a stronger functional embedding of the hippocampus in the DMN.
背景/目的：耐力运动可以改善多发性硬化症患者（pwMS）的记忆功能，但目前尚不清楚其对海马功能的影响。我们研究了跑步干预对 pwMS 记忆和海马功能连接的影响。
方法/结果：在跑步干预组（n=15）和候补组（n=14）中收集了记忆和静息状态功能磁共振成像（fMRI）数据。只有在干预组中，视空间记忆的改善与海马体与默认模式网络（DMN）之间的连接增加相关。
结论
由于耐力运动，视空间记忆的改善可能是通过海马体在 DMN 中的功能嵌入更强来介导的。
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