轻度颅脑创伤后血浆和尿液中 S-100β 蛋白的检测。
Detection of S-100β Protein in Plasma and Urine After a Mild Traumatic Brain Injury.
机构信息
Population Health and Optimal Health Practices, CHU de Québec Université Laval Research Center, Québec, QC, Canada.
Département de Médecine Familiale et Médecine d'Urgence, Faculté de Médecine, Université Laval, Québec, QC, Canada.
出版信息
Can J Neurol Sci. 2019 Sep;46(5):599-602. doi: 10.1017/cjn.2019.61. Epub 2019 Jul 18.
This study assessed whether S-100β protein could be measured in urine when detectable in plasma after a mild traumatic brain injury (mTBI). Clinical data, plasma and urine samples were collected for the 46 adult patients prospectively enrolled in the emergency department (ED) of a Level 1 trauma center. S-100β protein concentrations were analysed using ELISA. S-100β protein was detectable in 91% and 71% of plasma and urine samples, but values were not correlated (r = 0.002). Urine sampling would have been a non-invasive procedure, but it does not appear to be useful in the ED during the acute phase after an mTBI.
本研究评估了轻度创伤性脑损伤（mTBI）后，S-100β 蛋白在血浆中可检测到时，是否也可以在尿液中检测到。前瞻性纳入了 1 家 1 级创伤中心急诊科的 46 例成年患者，收集其临床数据、血浆和尿液样本。采用 ELISA 法分析 S-100β 蛋白浓度。91%和 71%的血浆和尿液样本中可检测到 S-100β 蛋白，但两者之间无相关性（r = 0.002）。尿液采集本是一种非侵入性的方法，但在 mTBI 后急性期的急诊科似乎没有用。
Zotero 插件