Ren Wen-Hao, Dong Kun, Huang Xiao-Zheng, Zhu Yan-Li
Key laboratory of Carcinogenesis and Translational Research (Ministry of Education), Department of Pathology, Peking University Cancer Hospital & Institute, Beijing, China.
Diagn Cytopathol. 2019 Nov;47(11):1197-1202. doi: 10.1002/dc.24281. Epub 2019 Jul 18.
Intrathyroidal thymic carcinoma is a malignant epithelial tumor of the thyroid gland with thymic epithelial differentiation; it is the malignant counterpart of ectopic thymoma of the thyroid gland and histologically resembles thymic carcinoma. Given its favorable prognostic course, preoperative cytological diagnosis is important to distinguish this neoplasm from other more aggressive thyroid neoplasms that can have similar or overlapping cytomorphological features. However, there is little information about the cytology of this disease available in the literature, even in the latest fourth edition of World Health Organization classification of tumors of endocrine organs. Here, we report a case of intrathyroidal thymic carcinoma exhibiting neuroendocrine differentiation in a 33-year-old woman and present a review of the literature.
甲状腺内胸腺癌是一种具有胸腺上皮分化的甲状腺恶性上皮性肿瘤；它是甲状腺异位胸腺瘤的恶性对应物，组织学上类似于胸腺癌。鉴于其预后良好，术前细胞学诊断对于将这种肿瘤与其他具有相似或重叠细胞形态特征的侵袭性更强的甲状腺肿瘤区分开来很重要。然而，即使在世界卫生组织内分泌器官肿瘤分类的最新第四版中，文献中关于这种疾病的细胞学信息也很少。在此，我们报告一例33岁女性甲状腺内胸腺癌伴神经内分泌分化的病例，并对文献进行综述。
