如何退烧：体温控制的反馈回路。
How to Break a Fever: A Feedback Circuit for Body Temperature Control.
机构信息
Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, MI 48109, USA.
Life Sciences Institute, University of Michigan, Ann Arbor, MI 48109, USA; Department of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI 48109, USA.
出版信息
Neuron. 2019 Jul 17;103(2):179-181. doi: 10.1016/j.neuron.2019.06.023.
Abstract
Body temperature control is a critical brain function. In this issue of Neuron, Wang et al. identify a negative feedback circuit in mouse preoptic area of the hypothalamus that regulates body temperature to counter fever.
摘要
体温控制是一项关键的大脑功能。在本期《神经元》杂志上，Wang 等人确定了小鼠下丘脑视前区的一个负反馈回路，该回路调节体温以对抗发热。
相似文献
1
How to Break a Fever: A Feedback Circuit for Body Temperature Control.如何退烧：体温控制的反馈回路。
Neuron. 2019 Jul 17;103(2):179-181. doi: 10.1016/j.neuron.2019.06.023.
2
Thermoregulation via Temperature-Dependent PGD Production in Mouse Preoptic Area.通过小鼠视前区温度依赖性 PGD 产生进行体温调节。
Neuron. 2019 Jul 17;103(2):309-322.e7. doi: 10.1016/j.neuron.2019.04.035. Epub 2019 May 28.
3
Preoptic anterior hypothalamic thermosensitivity during fever production by prostaglandin E1.前列腺素E1致热过程中视前区下丘脑前部的热敏性
Isr J Med Sci. 1976 Sep;12(9):1056-9.
4
Mice keep their cool.老鼠能保持冷静。
Nat Rev Neurosci. 2019 Aug;20(8):448-449. doi: 10.1038/s41583-019-0198-1.
5
Immune-Induced Fever Is Dependent on Local But Not Generalized Prostaglandin E Synthesis in the Brain.免疫诱导的发热取决于大脑中局部而非全身性前列腺素E的合成。
J Neurosci. 2017 May 10;37(19):5035-5044. doi: 10.1523/JNEUROSCI.3846-16.2017. Epub 2017 Apr 24.
6
Central Mechanisms of Thermoregulation and Fever in Mammals.哺乳动物体温调节和发热的中枢机制。
Adv Exp Med Biol. 2024;1461:141-159. doi: 10.1007/978-981-97-4584-5_10.
7
Role of the preoptic-anterior hypothalamus in thermoregulation and fever.视前区-下丘脑前部在体温调节和发热中的作用。
Clin Infect Dis. 2000 Oct;31 Suppl 5:S157-61. doi: 10.1086/317521.
8
EP3R-Expressing Glutamatergic Preoptic Neurons Mediate Inflammatory Fever.表达 EphA4 的谷氨酸能性视前区神经元介导电炎性发热
J Neurosci. 2020 Mar 18;40(12):2573-2588. doi: 10.1523/JNEUROSCI.2887-19.2020. Epub 2020 Feb 20.
9
10
The effects of prostaglandin E2 on the firing rate activity of thermosensitive and temperature insensitive neurons in the ventromedial preoptic area of the rat hypothalamus.前列腺素E2对大鼠下丘脑腹内侧视前区热敏和温度不敏感神经元放电频率活动的影响。
Brain Res. 2003 Feb 21;964(1):42-50. doi: 10.1016/s0006-8993(02)04063-5.
引用本文的文献
1
Living Control Systems: Exploring a Teleonomic Account of Behavior in .生命控制系统：探索一种关于行为的目的论解释
Insects. 2025 Aug 16;16(8):848. doi: 10.3390/insects16080848.
2
Validation of Targeted Relationships of Novel circRNA803/lncRNA MSTRG.19726-oar-let-7a-CPEB1 ceRNA Networks, Key to Follicle Development in Single-Litter and Multi-Litter Sheep Based on Whole-Transcriptome Sequencing.基于全转录组测序的单胎和多胎绵羊卵泡发育关键新circRNA803/lncRNA MSTRG.19726-oar-let-7a-CPEB1 ceRNA网络靶向关系验证
Int J Mol Sci. 2025 May 28;26(11):5161. doi: 10.3390/ijms26115161.
3
RNA-seq revealed the effects of heat stress on different brain regions of .RNA测序揭示了热应激对……不同脑区的影响。 （原句中“of”后面缺少具体内容）
Front Physiol. 2025 May 13;16:1579499. doi: 10.3389/fphys.2025.1579499. eCollection 2025.
4
Comprehensive Profiling of ceRNA (circRNA-miRNA-mRNA) Networks in Hypothalamic-Pituitary-Mammary Gland Axis of Dairy Cows under Heat Stress.热应激对奶牛下丘脑-垂体-乳腺轴 ceRNA（circRNA-miRNA-mRNA）网络的综合分析
Int J Mol Sci. 2023 Jan 3;24(1):888. doi: 10.3390/ijms24010888.
5
Predicting the location of the preoptic and anterior hypothalamic region by visualizing the thermoregulatory center on fMRI in craniopharyngioma using cold and warm stimuli.使用冷、热刺激在 fMRI 上可视化体温调节中枢预测颅咽管瘤术前视前区和下丘脑前部的位置。
Aging (Albany NY). 2021 Mar 26;13(7):10087-10098. doi: 10.18632/aging.202766.
本文引用的文献
1
Thermoregulation via Temperature-Dependent PGD Production in Mouse Preoptic Area.通过小鼠视前区温度依赖性前列腺素D合成进行体温调节。
Neuron. 2019 Jul 17;103(2):349. doi: 10.1016/j.neuron.2019.06.026.
2
Central Mechanisms for Thermoregulation.体温调节的中枢机制。
Annu Rev Physiol. 2019 Feb 10;81:285-308. doi: 10.1146/annurev-physiol-020518-114546. Epub 2018 Sep 26.
3
Warm-Sensitive Neurons that Control Body Temperature.控制体温的热敏神经元。
Cell. 2016 Sep 22;167(1):47-59.e15. doi: 10.1016/j.cell.2016.08.028. Epub 2016 Sep 8.
4
The TRPM2 channel is a hypothalamic heat sensor that limits fever and can drive hypothermia.瞬时受体电位M2型（TRPM2）通道是一种下丘脑热传感器，可限制发热并引发体温过低。
Science. 2016 Sep 23;353(6306):1393-1398. doi: 10.1126/science.aaf7537. Epub 2016 Aug 25.
5
Trp ion channels and temperature sensation.色氨酸离子通道与温度感知。
Annu Rev Neurosci. 2006;29:135-61. doi: 10.1146/annurev.neuro.29.051605.112958.
6
Prostaglandin D synthase: structure and function.前列腺素D合酶：结构与功能
Vitam Horm. 2000;58:89-120. doi: 10.1016/s0083-6729(00)58022-4.
7
Temperature receptors in the central nervous system.中枢神经系统中的温度感受器。
Annu Rev Physiol. 1986;48:639-54. doi: 10.1146/annurev.ph.48.030186.003231.
Zotero 插件