The Goldman Medical School at the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Department of Obstetrics and Gynecology, Soroka University Medical Center, Beer-Sheva, Israel.
Early Hum Dev. 2019 Sep;136:54-59. doi: 10.1016/j.earlhumdev.2019.07.002. Epub 2019 Jul 15.
Urinary tract infection (UTI) is a common bacterial infection in pregnant women and is associated with adverse perinatal outcomes. We sought to investigate the long-term infectious outcomes of children to mothers who were diagnosed with UTI during their pregnancy.
A population-based cohort analysis was conducted at a single tertiary medical center. The study included all singleton deliveries between the years 1991-2014, comparing offspring born to mothers diagnosed with UTI during their pregnancy with those born to non-exposed mothers. Infectious-related hospitalizations of the offspring up to the age of 18 years were assessed according to a predefined set of ICD-9 codes. A Kaplan-Meier survival curve was conducted to compare cumulative hospitalization incidence between the groups. A Cox regression model was used to adjust for confounders.
During the study period, 243,725 deliveries met the inclusion criteria. Of them, 8034 (3.3%) were exposed to maternal UTI during pregnancy. Infectious-related hospitalizations were significantly prevalent in offspring to exposed mothers (12.3% vs. 11.0%, OR = 1.125, 95% CI 1.051-1.204, Kaplan-Meier log rank p < 0.001). In the Cox regression model, while controlling for clinically relevant confounders, maternal UTI (adjuster HR = 1.240), as well as preterm delivery (adjusted HR = 1.385) and cesarean delivery (adjusted HR = 1.198) were noted as independent risk factors for long-term infectious morbidity of the offspring.
Maternal UTI in pregnancy may influence offspring susceptibility to pediatric infections, as it was found to be an independent risk factor for long-term infectious morbidity of the offspring.
尿路感染（UTI）是孕妇常见的细菌感染，与围产期不良结局有关。我们旨在研究母亲在怀孕期间被诊断为 UTI 的情况下，其子女的长期感染结局。
在一家三级医疗中心进行了一项基于人群的队列分析。该研究纳入了 1991 年至 2014 年间所有的单胎分娩，比较了在母亲怀孕期间被诊断为 UTI 的婴儿与未暴露于 UTI 的母亲所生婴儿。根据一组预定义的 ICD-9 编码评估了子女在 18 岁之前的感染相关住院情况。采用 Kaplan-Meier 生存曲线比较两组的累积住院发生率。采用 Cox 回归模型调整混杂因素。
在研究期间，有 243725 例分娩符合纳入标准。其中，8034 例（3.3%）在妊娠期间暴露于母亲的 UTI。暴露于母亲 UTI 的子女感染相关住院的发生率明显更高（12.3%比 11.0%，OR=1.125，95%CI 1.051-1.204，Kaplan-Meier 对数秩检验 p<0.001）。在 Cox 回归模型中，在控制了临床相关混杂因素后，母亲 UTI（调整后的 HR=1.240）以及早产（调整后的 HR=1.385）和剖宫产（调整后的 HR=1.198）被认为是子女长期感染发病率的独立危险因素。
孕妇 UTI 可能会影响子女对儿科感染的易感性，因为它被认为是子女长期感染发病率的独立危险因素。
