The Goldman Medical School at the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
Department of Public Health, Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel.
J Dev Orig Health Dis. 2022 Aug;13(4):508-513. doi: 10.1017/S2040174421000593. Epub 2021 Oct 28.
Asymptomatic bacteriuria (ASB) is a well-acknowledged infectious entity during pregnancy; yet its long-term implications are not well investigated. The present study aimed to test the association between maternal ASB during pregnancy and long-term offspring infectious hospitalizations. A population-based cohort analysis was conducted, comparing the incidence of long-term infectious-related hospitalizations of offspring born to mothers who were diagnosed with ASB during pregnancy, and those who did not have ASB. The study was conducted at a tertiary medical center and included all singleton deliveries between the years 1991 and 2014. Infectious morbidities were based on a predefined set of International Classification of Disease-9 codes. A Kaplan-Meier survival curve compared cumulative infectious hospitalization incidence between the groups, and a Cox regression model was used to adjust for confounding variables. During the study period, 212,984 deliveries met inclusion criteria. Of them, 5378 (2.5%) were diagnosed with ASB. As compared to offspring of non-ASB mothers, total long-term infectious hospitalizations were significantly higher among children to mothers who were diagnosed with ASB (13.1% vs. 11.1%, OR = 1.2, 95% CI 1.11-1.30, ≤ 0.001). Likewise, a Kaplan-Meier curve demonstrated higher cumulative incidence of infectious hospitalizations among children born to mothers with ASB (log rank, = 0.006). In the Cox regression model, while controlling for maternal age, diabetes mellitus, ethnicity, hypertensive disorders, and gestational age, maternal ASB was noted as an independent risk factor for long-term infectious morbidity in the offspring (adjusted HR = 1.1, 95% CI 1.01-1.17, = 0.042). ASB during pregnancy increases offspring susceptibility to long-term infectious hospitalizations.
无症状菌尿症（ASB）是妊娠期间公认的感染性疾病；然而，其长期影响尚未得到充分研究。本研究旨在检测妊娠期间母体 ASB 与长期后代感染性住院之间的关联。进行了一项基于人群的队列分析，比较了在妊娠期间被诊断为 ASB 的母亲所生的后代与没有 ASB 的母亲所生的后代的长期感染相关住院的发生率。该研究在一家三级医疗中心进行，纳入了 1991 年至 2014 年期间所有的单胎分娩。感染性疾病是根据预先定义的国际疾病分类第 9 版代码确定的。Kaplan-Meier 生存曲线比较了两组之间的累积感染住院发生率，Cox 回归模型用于调整混杂变量。在研究期间，有 212984 例分娩符合纳入标准。其中，5378 例（2.5%）被诊断为 ASB。与非 ASB 母亲的后代相比，患有 ASB 的母亲的后代的总长期感染性住院率明显更高（13.1% vs. 11.1%，OR = 1.2，95%CI 1.11-1.30， ≤ 0.001）。同样，Kaplan-Meier 曲线显示患有 ASB 的母亲所生的儿童的累积感染性住院发生率更高（对数秩检验， = 0.006）。在 Cox 回归模型中，在校正了母亲年龄、糖尿病、种族、高血压疾病和胎龄等因素后，母体 ASB 被认为是后代长期感染性发病率的独立危险因素（调整 HR = 1.1，95%CI 1.01-1.17， = 0.042）。妊娠期间的 ASB 增加了后代发生长期感染性住院的易感性。
