A chronological study of experimental scrapie in mice.

The development of scrapie-associated particles and lesions in four regions of the brain was studied in mice over a period of 30 weeks. Characteristic tubulovesicular particles, identical to those previously described, were first found about half way through the incubation period in mice inoculated by four different routes. The particles are found in brains with scrapie and other spongiform encephalopathies; they have never been seen in other conditions, and potentially represent the infectious agent.