Battaglia Yuri, Cojocaru Elena, Fiorini Fulvio, Granata Antonio, Esposito Pasquale, Russo Luigi, Bortoluzzi Alessandra, Storari Alda, Russo Domenico
Clin Nephrol. 2020 Feb;93(2):57-64. doi: 10.5414/CN109735.
Kidney transplant recipients (KTRs) are susceptible to low levels of vitamin D, which may be responsible for mineral and bone metabolism disorders and play some role in the occurrence of cardiovascular, metabolic, immunologic, neoplastic, and infectious complications after kidney transplant. Kidney Disease Improving Global Outcomes (KDIGO) guidelines of the year 2017 recommended vitamin D supplementation in the first 12 months after transplant using the same treatment strategies for the general population. However, no recommendations are provided after the first 12 months due to a lack of sufficient data. This review analyses some studies that assessed the vitamin D status of KTRs and the effects of nutritional and active vitamin D supplementation on bone mineral density, cardiovascular disease, proteinuria, and graft function in KTRs.
肾移植受者（KTRs）易患维生素D水平低下，这可能是矿物质和骨代谢紊乱的原因，并且在肾移植后心血管、代谢、免疫、肿瘤和感染性并发症的发生中起一定作用。2017年改善全球肾脏病预后组织（KDIGO）指南建议，在移植后的前12个月对肾移植受者补充维生素D，采用与普通人群相同的治疗策略。然而，由于缺乏足够的数据，在12个月之后未给出相关建议。本综述分析了一些评估肾移植受者维生素D状态以及营养性和活性维生素D补充剂对肾移植受者骨矿物质密度、心血管疾病、蛋白尿和移植肾功能影响的研究。
