Dodig Novaković Maja, Lovrić Kojundžić Sanja, Radić Mislav, Vučković Marijana, Gelemanović Andrea, Roguljić Marija, Kovačević Katja, Orešković Josip, Radić Josipa
Department of Radiology, General Hospital Šibenik, 22000 Šibenik, Croatia.
Department of Diagnostic and Interventional Radiology, University Hospital of Split, 21000 Split, Croatia.
J Pers Med. 2022 Jun 16;12(6):984. doi: 10.3390/jpm12060984.
Although kidney transplantation significantly improves the quality of life of patients with end-stage renal disease (ESRD), the prevalence of cardiovascular disease (CVD) in kidney transplant recipients (KTRs) remains high. Atherosclerosis, post-transplantation metabolic changes, immunosuppressive therapy, and periodontitis contribute to elevated cardiovascular risk in this population. The aim of the study was to evaluate carotid intima-media thickness (IMT) as a surrogate marker of atherosclerosis and to analyze the possible risk factors for IMT in Dalmatian KTRs. Ninety-three KTRs were included in this study. Data on clinical and laboratory parameters, body composition, anthropometry, advanced glycation end-product (AGE) measurements, blood pressure, and arterial stiffness were collected. All participants underwent ultrasound examination of IMT and evaluation of periodontal status. KTRs with carotid IMT ≥ 0.9 were significantly older, had a lower level of total cholesterol, fat mass, end-diastolic velocity (EDV), and had fewer teeth. They also had significantly higher values of pulse wave velocity (PWV) and resistive index (RI). We found positive correlations between carotid IMT and duration of dialysis, age, PWV, AGE, RI, and average total clinical attachment level (CAL). The regression model showed that IMT in KTRs is associated with higher PWV, lower fat mass, and fewer teeth. The results of our study suggest that nutritional and periodontal status are associated with carotid IMT in KTRs.
尽管肾移植显著改善了终末期肾病（ESRD）患者的生活质量，但肾移植受者（KTRs）中心血管疾病（CVD）的患病率仍然很高。动脉粥样硬化、移植后代谢变化、免疫抑制治疗和牙周炎导致该人群心血管风险升高。本研究的目的是评估颈动脉内膜中层厚度（IMT）作为动脉粥样硬化的替代标志物，并分析达尔马提亚KTRs中IMT的可能危险因素。本研究纳入了93名KTRs。收集了临床和实验室参数、身体成分、人体测量学、晚期糖基化终产物（AGE）测量值、血压和动脉僵硬度的数据。所有参与者均接受了IMT的超声检查和牙周状况评估。颈动脉IMT≥0.9的KTRs年龄显著更大，总胆固醇水平、脂肪量、舒张末期速度（EDV）更低，牙齿数量更少。他们的脉搏波速度（PWV）和阻力指数（RI）值也显著更高。我们发现颈动脉IMT与透析持续时间、年龄、PWV、AGE、RI以及平均总临床附着水平（CAL）之间存在正相关。回归模型显示，KTRs中的IMT与更高的PWV、更低的脂肪量和更少的牙齿有关。我们的研究结果表明，营养和牙周状况与KTRs中的颈动脉IMT相关。
