West Pomeranian University of Technology, Faculty of Chemical Technology and Engineering, Institute of Organic Chemical Technology, ul. Pulaskiego 10, 70-322 Szczecin, Poland.
Empa, Swiss Federal Laboratories for Materials Science and Technology, Laboratory for Protection and Physiology, CH-9014 St. Gallen, Switzerland.
Carbohydr Polym. 2019 Oct 15;222:115014. doi: 10.1016/j.carbpol.2019.115014. Epub 2019 Jun 21.
The films based on carboxymethyl derivatives of starch (CMS) and cellulose (CMC) were proposed as a novel human skin equivalent. The physicochemical properties (moisture absorption, solubility in water, mechanical properties) of CMS/CMC films were evaluated. Additionally, some properties were compared to the human skin ones (surface roughness, tribology). The system based on CMS/CMC 25/75 wt. % was selected for testing the adhesive properties of pressure-sensitive adhesives commonly used for medical purposes (acrylic, silicone and polyisobutylene). Similar tests were performed for human skin. The peel adhesion values for CMS/CMC film and human skin were similar for all adhesives types tested. Applying such a skin equivalent allows to evaluate the functional properties of medical pressure-sensitive adhesives without the ethical and economic issues.
以淀粉（CMS）和纤维素（CMC）的羧甲基衍生物为基础的薄膜被提议作为一种新型的人类皮肤等效物。评估了 CMS/CMC 薄膜的物理化学性质（吸湿、水溶解度、机械性能）。此外，还将一些性能与人体皮肤的性能（表面粗糙度、摩擦学）进行了比较。选择基于 CMS/CMC 25/75wt.%的系统来测试常用于医疗目的的压敏粘合剂（丙烯酸、硅酮和聚异丁烯）的粘合性能。对人体皮肤进行了类似的测试。对于所有测试的粘合剂类型，CMS/CMC 薄膜和人体皮肤的剥离粘合值都相似。使用这种皮肤等效物可以在没有伦理和经济问题的情况下评估医用压敏粘合剂的功能特性。
