5-氟尿嘧啶消除R46 R因子的紫外线抗性诱导效应
Elimination of UV-resistance inducing effect of R46 R factor by 5-fluorouracil.
作者信息
Francia I, Hernádi Z, Szabolcs M, Hernádi F
机构信息
Central Research Laboratory, University Medical School, Debrecen, Hungary.
出版信息
Acta Biochim Biophys Hung. 1987;22(4):491-6.
PMID:3132007
Abstract
R-factor curing capacity of 5-fluorouracil (5-FU) was studied. Well detectable increase in UV-resistance was found in E. coli K12 AB1157 strain and its recB-, recC-, recF- mutants harbouring R46 R-factor. After treatment with 5-FU, these strains lost not only the antibiotic resistance coded for R46 R-factor but their UV-radioresistance, as well.
摘要
研究了5-氟尿嘧啶（5-FU）的R因子治愈能力。在携带R46 R因子的大肠杆菌K12 AB1157菌株及其recB-、recC-、recF-突变体中发现紫外线抗性有明显增加。用5-FU处理后，这些菌株不仅失去了R46 R因子编码的抗生素抗性，还失去了它们的紫外线辐射抗性。
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