血浆游离氨基酸指数对糖尿病合并胰腺癌的诊断价值。
Diagnostic yield of the plasma free amino acid index for pancreatic cancer in patients with diabetes mellitus.
机构信息
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
Department of Gastroenterology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; Department of Gastroenterology, Graduate School of Medicine, Juntendo University, Tokyo, Japan.
出版信息
Pancreatology. 2019 Jul;19(5):695-698. doi: 10.1016/j.pan.2019.07.002. Epub 2019 Jul 13.
OBJECTIVES
A multivariate index calculated using plasma free amino acids (PFAA index) was reported as a diagnostic biomarker for pancreatic cancer (PaC). Although diabetes mellitus (DM) is expected to be an early diagnostic indicator of PaC, identifying the high-risk individuals among patients with DM is warranted. We evaluated the diagnostic yield of the PFAA index for PaC in patients with DM.
METHODS
We compared the diagnostic yield of the PFAA index between individuals with and those without DM. Cases and controls were recruited prospectively, and controls were matched to cases at a 1:1 ratio for age, sex, and DM status.
RESULTS
A total of 180 case-control pairs were included in the analysis. The prevalence of DM was 53.3%. The sensitivity of the PFAA index was 66.7% in cases with DM and 56.0% in those without DM (P = 0.14), and the specificity was 92.7% in controls with DM and 94.0% in those without DM (P = 0.95).
CONCLUSIONS
This matched case-control study revealed a comparable diagnostic yield of the PFAA index for PaC in individuals with and those without DM. The PFAA index can be used as a biomarker for further diagnostic imaging in selected patients with DM.
目的
使用血浆游离氨基酸（PFAA 指数）计算的多变量指数被报道为胰腺癌（PaC）的诊断生物标志物。尽管糖尿病（DM）预计是 PaC 的早期诊断指标，但需要确定 DM 患者中的高危个体。我们评估了 PFAA 指数在 DM 患者中对 PaC 的诊断效果。
方法
我们比较了 DM 患者和非 DM 患者中 PFAA 指数的诊断效果。病例和对照前瞻性招募，对照与病例按年龄、性别和 DM 状态 1:1 匹配。
结果
共纳入 180 对病例对照。DM 的患病率为 53.3%。DM 患者中 PFAA 指数的敏感性为 66.7%，而非 DM 患者为 56.0%（P=0.14），DM 对照中 PFAA 指数的特异性为 92.7%，而非 DM 对照为 94.0%（P=0.95）。
结论
这项匹配病例对照研究显示，PFAA 指数对 DM 患者和非 DM 患者的 PaC 诊断效果相当。PFAA 指数可作为有选择的 DM 患者进一步诊断成像的生物标志物。
Zotero 插件