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社会地位与基因调控:灵长类动物中的保守性与情境依赖性

Social Status and Gene Regulation: Conservation and Context Dependence in Primates.

机构信息

Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA.

Department of Evolutionary Anthropology, Duke University, Durham, NC 27708, USA; Department of Biology, Duke University, Durham, NC 27708, USA; Duke Population Research Institute, Duke University, Durham, NC 27708, USA; Institute of Primate Research, National Museums of Kenya, 00502 Nairobi, Kenya.

出版信息

Trends Cogn Sci. 2019 Sep;23(9):722-725. doi: 10.1016/j.tics.2019.06.003. Epub 2019 Jul 15.

DOI:10.1016/j.tics.2019.06.003
PMID:31320266
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC7101489/
Abstract

Current models suggest that low social status affects immune function by increasing inflammation and compromising antiviral defense. While this pattern appears to be somewhat conserved, recent studies argue that the gene regulatory signature of social status also depends on the local environment and the nature of social hierarchies.

摘要

目前的模型表明,低社会地位通过增加炎症和损害抗病毒防御来影响免疫功能。虽然这种模式似乎有些保守,但最近的研究认为,社会地位的基因调控特征也取决于局部环境和社会等级制度的性质。

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The Conserved Transcriptional Response to Adversity.对逆境的保守转录反应。
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Traumatic events and mental health: The amplifying effects of pre-trauma systemic inflammation.创伤事件与心理健康:创伤前系统性炎症的放大效应。
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High social status males experience accelerated epigenetic aging in wild baboons.高社会地位的雄性野生狒狒经历加速的表观遗传衰老。
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社会地位改变了食蟹猴染色质可及性和糖皮质激素刺激的基因调控反应。
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1219-1228. doi: 10.1073/pnas.1811758115. Epub 2018 Dec 11.
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Dominance rank-associated gene expression is widespread, sex-specific, and a precursor to high social status in wild male baboons.与统治等级相关的基因表达是普遍存在的、性别特异性的,并且是野生雄性狒狒获得高社会地位的前兆。
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