Biology Center of the Czech Academy of Sciences, Branisovska 31, 37005 Budweis, (Ceske Budejovice), Czechia.
Dpto. de Genética, Facultad de Ciencias, Universidad de Granada, Campus de Fuentenueva s/n, 18071, Granada, Spain; Lab. de Bioinformática, Centro de Investigación Biomédica (CIBM), PTS, Avda. del Conocimiento s/n, 18100, Granada, Spain.
Trends Parasitol. 2019 Sep;35(9):715-724. doi: 10.1016/j.pt.2019.06.012. Epub 2019 Jul 15.
Systems biology approaches, especially in the big data era, have revolutionized modern parasitology. Of the many different molecules participating in parasite-host interactions, noncoding RNAs (ncRNAs) are now known to be (i) transmitted by the vector to possibly modulate vertebrate host responses and favor vector survival and (ii) regulated in the host by parasites to favor parasite survival. Here we provide an overview of the involvement of ncRNAs in the parasite-vector-host triad and their effect on host homeostasis based on recent advances and accumulating knowledge about the role of endogenous vertebrate noncoding RNAs in vertebrate host physiology.
系统生物学方法，尤其是在大数据时代，彻底改变了现代寄生虫学。在参与寄生虫-宿主相互作用的众多不同分子中，非编码 RNA（ncRNA）现在已知：(i) 通过媒介传播，可能调节脊椎动物宿主的反应，并有利于媒介的存活；(ii) 在宿主中受到寄生虫的调控，有利于寄生虫的存活。基于最近在脊椎动物宿主生理学中内源性非编码 RNA 作用方面的进展和不断积累的知识，本文概述了 ncRNA 在寄生虫-媒介-宿主三元体中的作用及其对宿主动态平衡的影响。
