Department of Biochemistry and Molecular Biology, University of Bielsko-Biala, Faculty of Health Sciences, Willowa St. 2, 43-309, Bielsko-Biała, Poland.
Heart Fail Rev. 2019 Jul;24(4):575-586. doi: 10.1007/s10741-019-09770-9.
Myocardial infarction and post-infarction left ventricular remodelling involve a high risk of morbidity and mortality. For this reason, ongoing research is being conducted in order to learn the mechanisms of unfavourable left ventricular remodelling following a myocardial infarction. New biomarkers are also being sought that would allow for early identification of patients with a high risk of post-infarction remodelling and dysfunction of the left ventricle. In recent years, there has been ever more experimental data that confirms the significance of microRNA in cardiovascular diseases. It has been confirmed that microRNAs are stable in systemic circulation, and can be directly measured in patients' blood. It has been found that significant changes occur in the concentrations of various types of microRNA in myocardial infarction and heart failure patients. Various types of microRNA are also currently being intensively researched in terms of their usefulness as markers of cardiomyocyte necrosis, and predictors of the post-infarction heart failure development. This paper is a summary of the current knowledge on the significance of microRNA in post-infarction left ventricular remodelling and heart failure.
心肌梗死和梗死后左心室重构会带来很高的发病率和死亡率。因此，目前正在进行研究，以了解心肌梗死后左心室重构不良的机制。还在寻找新的生物标志物，以便能够早期识别具有梗死后左心室重构和功能障碍高风险的患者。近年来，越来越多的实验数据证实了 microRNA 在心血管疾病中的重要性。已经证实，microRNA 在全身循环中稳定存在，并且可以直接在患者的血液中测量。已经发现，在心肌梗死和心力衰竭患者中，各种类型的 microRNA 的浓度会发生显著变化。目前，各种类型的 microRNA 也正在作为心肌细胞坏死的标志物和预测梗死后心力衰竭发展的指标进行深入研究。本文总结了 microRNA 在梗死后左心室重构和心力衰竭中的重要作用的最新知识。
