Sury M R, Cole P V
Anaesthetics Laboratory, St Bartholomew's Hospital, West Smithfield, London.
Anaesthesia. 1988 Apr;43(4):285-8. doi: 10.1111/j.1365-2044.1988.tb08974.x.
Forty patients who required day case fibreoptic bronchoscopy were sedated with either nalbuphine 0.2 mg/kg and midazolam 0.05 mg/kg (n = 20), or midazolam 0.05 mg/kg alone (n = 20). Extra midazolam was administered when required. The degree of respiratory depression measured by arterialised venous carbon dioxide levels was recorded together with heart rate, arterial blood pressure, respiratory rate and sedation score, before administration of the drugs and at regular intervals thereafter. Patients who received nalbuphine had slightly higher carbon dioxide levels but respiratory rate and cardiovascular changes were similar in both groups. The addition of nalbuphine to midazolam improves the quality of sedation but prolongs the recovery time and increases the incidence of side effects.
40例需要日间进行纤维支气管镜检查的患者，分别用0.2mg/kg纳布啡和0.05mg/kg咪达唑仑（n = 20）或单用0.05mg/kg咪达唑仑（n = 20）进行镇静。必要时追加咪达唑仑。在给药前及此后定期记录通过动脉化静脉血二氧化碳水平测量的呼吸抑制程度，以及心率、动脉血压、呼吸频率和镇静评分。接受纳布啡的患者二氧化碳水平略高，但两组的呼吸频率和心血管变化相似。在咪达唑仑中加入纳布啡可改善镇静质量，但会延长恢复时间并增加副作用发生率。
