Chin K W, Tan P K, Chin M K
Department of Anaesthesia, Tan Tock Seng Hospital, Singapore.
Ann Acad Med Singap. 1994 May;23(3):330-2.
Forty patients received either midazolam or midazolam with nalbuphine in a double-blind randomised study of sedation for upper gastrointestinal endoscopy. There were less retching, gagging and salivation in the combination group compared to midazolam alone. They were also more cooperative. These resulted in greater ease of insertion of the gastroscope. There was no significant difference in the degree of amnesia in both groups. A significant decrease in oxygen saturation was noted in both groups during the procedure. Monitoring with a pulse oximeter is recommended when sedation is administered during gastroscopy.
在一项关于上消化道内镜检查镇静的双盲随机研究中，40名患者接受了咪达唑仑或咪达唑仑联合纳布啡治疗。与单独使用咪达唑仑相比，联合组的干呕、 gagging和流涎情况较少。他们也更合作。这些使得胃镜插入更加容易。两组的遗忘程度没有显著差异。在检查过程中，两组的血氧饱和度均显著下降。建议在胃镜检查期间给予镇静时使用脉搏血氧仪进行监测。
