Houriet Carine, Haneke Eckart
Department of Dermatology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland.
Case Rep Dermatol. 2019 Jun 26;11(2):175-179. doi: 10.1159/000500946. eCollection 2019 May-Aug.
Cogan syndrome and lichen planus represent two autoimmune disorders. Cogan syndrome is a very rare type of ANCA-negative vasculitis affecting the eyes and vestibulocochlear system. It has been associated with other autoimmune disorders, none of them showing any lichenoid inflammation. We herein report the first case of a patient that suffered from Cogan disease and developed isolated lichen planus on all nails a few years after the first diagnosis. The combination of two autoimmune disorders is not unusual and raises the question of common immunogenetic pathomechanisms.
科根综合征和扁平苔藓是两种自身免疫性疾病。科根综合征是一种非常罕见的抗中性粒细胞胞浆抗体（ANCA）阴性血管炎，可累及眼睛和前庭蜗神经。它与其他自身免疫性疾病有关，但均未表现出任何苔藓样炎症。我们在此报告首例科根病患者，在首次诊断几年后，所有指甲均出现孤立性扁平苔藓。两种自身免疫性疾病的合并并不罕见，这引发了关于共同免疫遗传发病机制的问题。
