St. John's Institute of Dermatology, King's College London, Guy's Hospital, London, United Kingdom.
St. John's Institute of Dermatology, King's College London, Guy's Hospital, London, United Kingdom.
J Am Acad Dermatol. 2018 Nov;79(5):789-804. doi: 10.1016/j.jaad.2018.02.010.
Deriving from the Greek word λειχήν for "tree moss" and the Latin word planus for "planar," lichen planus is a relatively uncommon and heterogeneous cutaneous disorder that typically develops in middle-aged adults. Despite the significant clinical burden associated with the disorder, little well-conducted molecular research has been undertaken, possibly because of heterogeneity impeding consistent and confident phenotyping. The multiple variants of lichenoid disease bear overlapping clinical and pathologic features despite manifesting as distinct clinical disorders. The first article in this 2-part continuing medical education series provides a comprehensive overview of the clinical and pathologic characteristics of cutaneous lichenoid dermatoses and links these manifestations to recent advances in our understanding of the underlying pathobiology of such diseases.
从希腊词“λειχήν”（意为“树苔”）和拉丁语“planus”（意为“平面的”）衍生而来，扁平苔藓是一种相对罕见且异质性的皮肤疾病，通常发生在中年成年人中。尽管该疾病具有显著的临床负担，但很少进行精心设计的分子研究，这可能是因为异质性阻碍了一致和自信的表型分析。尽管表现为不同的临床疾病，但多种苔藓样疾病变体具有重叠的临床和病理特征。本继续教育系列的第 1 部分的第 1 篇文章全面概述了皮肤苔藓样皮肤病的临床和病理特征，并将这些表现与我们对这些疾病潜在病理生物学的理解的最新进展联系起来。
