Kondo Makoto, Mizutani Minoru, Yamanaka Keiichi
Department of Dermatology, Mie University Graduate School of Medicine, Tsu, Japan.
Department of Hematology and Oncology, Matsusaka Chuo General Hospital, Matsusaka, Japan.
Case Rep Dermatol. 2019 Jun 26;11(2):194-197. doi: 10.1159/000501358. eCollection 2019 May-Aug.
We report a rare case of localized NK/T-cell lymphoma following a mosquito bite after achieving complete response of extranodal NK/T-cell lymphoma, nasal type (ENKL). T cells and NK cells infected by Epstein-Barr virus (EBV) lead to NK/T-cell lymphoma, including ENKL. Lymphoma related to mosquito bites usually requires a prolonged treatment course, and the disease onset of hypersensitivity begins in early childhood. In the current case, the patient had no history of hypersensitivity to mosquito bites. We speculate that the latently EBV-infected NK/T cells in the blood were reactivated by mosquito gland antigens, expanded abnormally, and accumulated at the site of the mosquito bite.
我们报告了1例罕见的局部NK/T细胞淋巴瘤病例，该病例发生在鼻型结外NK/T细胞淋巴瘤（ENKL）完全缓解后被蚊虫叮咬之后。受爱泼斯坦-巴尔病毒（EBV）感染的T细胞和NK细胞会导致NK/T细胞淋巴瘤，包括ENKL。与蚊虫叮咬相关的淋巴瘤通常需要较长的治疗疗程，且超敏反应的疾病发作始于儿童早期。在本病例中，患者既往无蚊虫叮咬过敏史。我们推测，血液中潜伏感染EBV的NK/T细胞被蚊虫腺体抗原重新激活，异常扩增，并在蚊虫叮咬部位积聚。
