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对抗精神病长效注射剂的积极看法:对开具抗精神病药物的社区患者的调查结果

Positive views on antipsychotic long-acting injections: results of a survey of community patients prescribed antipsychotics.

作者信息

Mace Shubhra, Chak Oscar, Punny Sharanjeet, Sedough-Abbasian Daniel, Vegad Chirag, Taylor David M

机构信息

Maudsley Hospital, Pharmacy Department, Denmark Hill, London SE5 8AZ, UK.

Maudsley Hospital, Pharmacy Department, Denmark Hill, London, UK.

出版信息

Ther Adv Psychopharmacol. 2019 Jul 3;9:2045125319860977. doi: 10.1177/2045125319860977. eCollection 2019.

Abstract

BACKGROUND

We aimed to assess patients' views about antipsychotic long-acting injections (LAIs).

METHODS

We interviewed patients prescribed an antipsychotic (oral or LAI) in our community teams. In a subanalysis, responses were analysed for differences between patients currently receiving an LAI and those prescribed only oral medication.

RESULTS

In total, 226 patients (57%) completed the study questionnaire. The majority agreed that LAIs ensured delivery of the right amount of medication and protection against hospital admissions (57% and 60%, respectively). A minority of participants were more concerned than not about the use of a needle (46%), pain from injection (48%) and the need to travel to receive the injection (34%). A majority expressed a preference for injection site (deltoid or gluteal) (65%) and clinic location (69%). A higher proportion of patients currently receiving an LAI compared with those prescribed oral medication thought an LAI was beneficial because this formulation obviated the need to: swallow tablets (63% 41%;  = 0.0013), remember to take tablets daily (75% 51%;  = 0.0004), remember tablets when away from home (72% 49%;  = 0008). Current LAI users were more likely than those on oral treatment to agree that LAIs keep patients out of hospital (76% 44%;  = 0.0001) and that the injection ensured delivery of the right amount of medication (71% 44%;  = 0.0002). Women were more likely than men to prefer administration by a clinician of the same gender (34% 12%;  = 0.0001).

CONCLUSIONS

In our study, a greater proportion of patients prescribed an LAI regarded LAIs as beneficial compared with those on oral medication.

摘要

背景

我们旨在评估患者对抗精神病长效注射剂(LAIs)的看法。

方法

我们对在社区团队中开具了抗精神病药物(口服或长效注射剂)的患者进行了访谈。在一项亚分析中,分析了目前接受长效注射剂治疗的患者与仅开具口服药物治疗的患者之间的反应差异。

结果

共有226名患者(57%)完成了研究问卷。大多数人认为长效注射剂能确保正确剂量的药物输送,并防止住院(分别为57%和60%)。少数参与者对使用针头(46%)、注射疼痛(48%)以及前往接受注射的必要性(34%)较为担忧。大多数人表示倾向于注射部位(三角肌或臀肌)(65%)和诊所位置(69%)。与口服药物治疗的患者相比,目前接受长效注射剂治疗的患者中,有更高比例的人认为长效注射剂有益,因为这种剂型无需:吞服片剂(63%对41%;P = 0.0013)、每天记得服药(75%对51%;P = 0.0004)、离家时记得带药(72%对49%;P = 0.008)。目前使用长效注射剂的患者比口服治疗的患者更有可能认同长效注射剂能使患者避免住院(76%对44%;P = 0.0001),并且注射能确保正确剂量的药物输送(71%对44%;P = 0.0002)。女性比男性更倾向于由同性别的临床医生进行给药(34%对12%;P = 0.0001)。

结论

在我们的研究中,与口服药物治疗的患者相比,开具长效注射剂的患者中更大比例的人认为长效注射剂有益。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1b08/6610435/cf1a1fc22d8d/10.1177_2045125319860977-fig1.jpg

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