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支化对具有偶极子与八极子电荷分布的阳离子三芳基硼发色团的单光子和双光子吸收、细胞活力和细胞定位的影响，用于细胞成像。

The Effect of Branching on the One- and Two-Photon Absorption, Cell Viability, and Localization of Cationic Triarylborane Chromophores with Dipolar versus Octupolar Charge Distributions for Cellular Imaging.

机构信息

Institut für Anorganische Chemie, and Institute for Sustainable Chemistry, & Catalysis with Boron, Julius-Maximilians-Universität Würzburg, 97074, Würzburg, Germany.

Institut für Organische Chemie, Julius-Maximilians-Universität Würzburg, 97074, Würzburg, Germany.

出版信息

Chemistry. 2019 Oct 11;25(57):13164-13175. doi: 10.1002/chem.201902461. Epub 2019 Sep 17.

DOI:10.1002/chem.201902461
PMID:31322301
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6857003/
Abstract

Two different chromophores, namely a dipolar and an octupolar system, were prepared and their linear and nonlinear optical properties as well as their bioimaging capabilities were compared. Both contain triphenylamine as the donor and a triarylborane as the acceptor, the latter modified with cationic trimethylammonio groups to provide solubility in aqueous media. The octupolar system exhibits a much higher two-photon brightness, and also better cell viability and enhanced selectivity for lysosomes compared with the dipolar chromophore. Furthermore, both dyes were applied in two-photon excited fluorescence (TPEF) live-cell imaging.

摘要

两种不同的生色团，即偶极子和八极子体系，被制备出来，并对它们的线性和非线性光学性质以及它们的生物成像能力进行了比较。两者都以三苯胺为供体，以三芳基硼烷为受体，后者用阳离子三甲铵基团修饰以提供在水介质中的溶解性。与偶极生色团相比，八极生色团表现出更高的双光子亮度，以及更好的细胞活力和增强的溶酶体选择性。此外，两种染料都被应用于双光子激发荧光（TPEF）活细胞成像。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/5c2a2d48bed3/CHEM-25-13164-g010.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/9eab28e3510a/CHEM-25-13164-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/4ff8b1dd56cc/CHEM-25-13164-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/8bca608c129a/CHEM-25-13164-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/2b3810f1bff9/CHEM-25-13164-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/c34acf3b0989/CHEM-25-13164-g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b942/6857003/43ca0d573dbe/CHEM-25-13164-g008.jpg
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