Dunkel Petra, Tran Christine, Rigault Delphine, Kontra Bence, Deprez Eric, Tauc Patrick, Mucsi Zoltán, Dhimane Hamid, Dalko Peter I
Pharmacological and Toxicological Chemistry and Biochemistry Laboratory, Université Paris Cité, 45 rue des Saints-Pères, Paris, 75270 cedex 05, France.
Department of Biological Chemistry, BrainVision Center Ltd, Liliom utca 43-45, 1094, Budapest, Hungary.
Chemistry. 2025 Aug 18;31(46):e01839. doi: 10.1002/chem.202501839. Epub 2025 Jul 22.
Multi-branched probes based on 2-hydroxymethylene 8-dimethylaminoquinoline (8-DMAQ) and triphenylamine (TPA) have been synthesized and compared under UV and femtosecond near-infrared two-photon (2P) activation conditions. While octupolar (3) and quadrupolar (2) DMAQ derivatives showed superior ε and 2P absorption cross-section (σ) values relative to the dipolar (1) probe, the fragmentation efficiency exhibited an inverse correlation with the enhanced absorption. Compound 1 emerged as the most effective probe reported to date for the release of organic substrates under both UV and 2P activation conditions at wavelengths accessible to commercially available lasers, achieving a quantum yield (Q) of 12% with σ = 86 GM and uncaging cross-section δ = 10.2 GM at 735 nm.
基于2-羟基亚甲基-8-二甲基氨基喹啉（8-DMAQ）和三苯胺（TPA）的多分支探针已被合成，并在紫外光和飞秒近红外双光子（2P）活化条件下进行了比较。虽然八极（3）和四极（2）DMAQ衍生物相对于偶极（1）探针显示出更高的ε和2P吸收截面（σ）值，但碎片化效率与增强的吸收呈负相关。化合物1是迄今为止报道的在商业可用激光器可及波长的紫外光和2P活化条件下用于释放有机底物的最有效探针，在735 nm处实现了12%的量子产率（Q），σ = 86 GM，解笼截面δ = 10.2 GM。
