钌催化的喹啉-氧化物的 C8-去氧区域选择性芳基化反应。
Ru-Catalyzed Deoxygenative Regioselective C8-H Arylation of Quinoline -Oxides.
机构信息
Department of Chemistry , Korea Advanced Institute of Science and Technology (KAIST) , Daejeon 34141 , South Korea.
Center for Catalytic Hydrocarbon Functionalization , Institute for Basic Science (IBS) , Daejeon 34141 , South Korea.
出版信息
J Org Chem. 2019 Oct 18;84(20):13150-13158. doi: 10.1021/acs.joc.9b01548. Epub 2019 Aug 1.
Regioselective C-H functionalization on quinolines is of high interest to lead to value-added products. Herein, we describe the development of Ru-catalyzed deoxygenative regioselective C8 arylation of quinoline -oxides with arylboronic esters. Mechanistic studies revealed that it proceeds in a tandem process of arylation and then deoxygenation, wherein both steps were found to be catalytic with the ruthenium species.
喹啉 C-H 功能化具有很高的应用价值，可以得到附加值高的产品。在此，我们描述了 Ru 催化的喹啉氧化物与芳基硼酸酯的脱氧化区域选择性 C8 芳基化反应。机理研究表明，该反应经历了芳基化和脱氧的串联过程，其中两个步骤都被发现与钌物种有关。
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