Departments of Bioengineering, Biosciences, and Chemistry and Center for Theoretical Biological Physics, Rice University, Houston, TX 77005.
Department of Biological Sciences, Virginia Tech, Blacksburg, VA 24061.
Mol Biol Cell. 2019 Jul 22;30(16):1882-1889. doi: 10.1091/mbc.E19-02-0107.
Over the past 50 years, the use of mathematical models, derived from physical reasoning, to describe molecular and cellular systems has evolved from an art of the few to a cornerstone of biological inquiry. George Oster stood out as a pioneer of this paradigm shift from descriptive to quantitative biology not only through his numerous research accomplishments, but also through the many students and postdocs he mentored over his long career. Those of us fortunate enough to have worked with George agree that his sharp intellect, physical intuition, and passion for scientific inquiry not only inspired us as scientists but also greatly influenced the way we conduct research. We would like to share a few important lessons we learned from George in honor of his memory and with the hope that they may inspire future generations of scientists.
在过去的 50 年中，从物理推理中得出的数学模型在描述分子和细胞系统方面的应用已经从少数人的艺术发展成为生物学研究的基石。George Oster 作为从描述性生物学到定量生物学这一范式转变的先驱，不仅通过他众多的研究成果，而且通过他在漫长的职业生涯中指导的许多学生和博士后研究员，脱颖而出。我们这些有幸与 George 共事的人都认为，他敏锐的才智、物理直觉和对科学研究的热情不仅激励了我们这些科学家，而且极大地影响了我们开展研究的方式。我们谨分享从 George 那里学到的一些重要经验，以纪念他，并希望这些经验能激励未来几代科学家。
