Department of Pharmacology, NEIGRIHMS, India.
Department of Radiation Oncology, NEIGRIHMS, India.
Br J Clin Pharmacol. 2019 Oct;85(10):2428-2435. doi: 10.1111/bcp.14064. Epub 2019 Aug 1.
This study prospectively quantified wastage of cancer chemotherapeutic drugs in an oncology unit to find the associated cost in 3 months. Retrospective analysis of drug usage for 12 months was also conducted to determine the expected drug loss in 1 year. The effect of vial sharing was evaluated under the assumption of sharing. A significant drug wastage of 19.72% (95% confidence interval [CI], 14.52-24.93%) in 3 months and 17.14% (95% CI 14.69-19.59%) in 1 year occurred in our oncology unit. Number of vials purchased (r = 0.362, p < 0.01), weight (r = -0.146, P < .01) and body surface area (r = -0.26, P < .01) correlated with the drug wasted. Vial sharing assumption showed a 9% (95% CI, 2.5-15.5%) reduction in cost in 1 year.
本研究前瞻性地量化了肿瘤科中癌症化疗药物的浪费情况，以在 3 个月内发现相关成本。还对 12 个月的药物使用情况进行了回顾性分析，以确定 1 年内预计的药物损失。在假设共享的情况下，评估了小瓶共享的效果。我们肿瘤科在 3 个月和 1 年内分别发生了 19.72%（95%置信区间 [CI]，14.52-24.93%）和 17.14%（95% CI 14.69-19.59%）的显著药物浪费。购买的小瓶数量（r=0.362，p<0.01）、重量（r=-0.146，P<.01）和体表面积（r=-0.26，P<.01）与浪费的药物相关。小瓶共享假设表明，1 年内成本降低了 9%（95%CI，2.5-15.5%）。
