• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

De novo generation of a functional human thymus from induced pluripotent stem cells.

作者信息

Chhatta Amiet R, Cordes Martijn, Hanegraaf Maaike A J, Vloemans Sandra, Cupedo Tom, Cornelissen Jan J, Carlotti Francoise, Salvatori Daniela, Pike-Overzet Karin, Fibbe Willem E, Hoeben Rob C, Mikkers Harald M M, Staal Frank J T

机构信息

Department of Immunohematology & Blood Transfusion, Leiden University Medical Center, Leiden, the Netherlands.

Department of Nephrology, Leiden University Medical Center, Leiden, the Netherlands.

出版信息

J Allergy Clin Immunol. 2019 Nov;144(5):1416-1419.e7. doi: 10.1016/j.jaci.2019.05.042. Epub 2019 Jul 16.

DOI:10.1016/j.jaci.2019.05.042
PMID:31323248
Abstract
摘要

相似文献

1
De novo generation of a functional human thymus from induced pluripotent stem cells.由诱导多能干细胞重新生成功能性人类胸腺。
J Allergy Clin Immunol. 2019 Nov;144(5):1416-1419.e7. doi: 10.1016/j.jaci.2019.05.042. Epub 2019 Jul 16.
2
Preservation of thymus functionality during in vivo culture in heterologous systems.在异源系统体内培养期间胸腺功能的保存。
Nat New Biol. 1972 Dec 27;240(104):285-6. doi: 10.1038/newbio240285a0.
3
Thymic microenvironment.
Bibl Haematol. 1984(48):293-320. doi: 10.1159/000408408.
4
Thymic Epithelial Cells Induced from Pluripotent Stem Cells by a Three-Dimensional Spheroid Culture System Regenerates Functional T Cells in Nude Mice.通过三维球体培养系统从多能干细胞诱导产生的胸腺上皮细胞在裸鼠体内再生功能性T细胞。
Cell Reprogram. 2015 Oct;17(5):368-75. doi: 10.1089/cell.2015.0006. Epub 2015 Sep 8.
5
Evidence for a functional second thymus in mice.小鼠体内存在功能性第二胸腺的证据。
Science. 2006 Apr 14;312(5771):284-7. doi: 10.1126/science.1123497. Epub 2006 Mar 2.
6
Replacing defective thymus function.替代有缺陷的胸腺功能。
Curr Opin Allergy Clin Immunol. 2020 Dec;20(6):541-548. doi: 10.1097/ACI.0000000000000695.
7
[Successful transplantation and functional maturation of the human thymus gland to the nude mouse].
Nihon Rinsho. 1976 Dec 10;34(12):3385-90.
8
Adult human autoimmune thymus transplantation into nude mice - functioning of human thymus epithelium in nude mice.将成年人类自身免疫性胸腺移植到裸鼠体内——人类胸腺上皮在裸鼠体内的功能
Biochem Exp Biol. 1978;14(2):101-6.
9
Efficient generation of functional pancreatic β-cells from human induced pluripotent stem cells.从人诱导多能干细胞高效生成功能性胰腺β细胞。
J Diabetes. 2017 Feb;9(2):168-179. doi: 10.1111/1753-0407.12400. Epub 2016 May 31.
10
Differentiation and transplantation of human induced pluripotent stem cell-derived otic epithelial progenitors in mouse cochlea.人诱导多能干细胞源性耳上皮祖细胞在小鼠耳蜗中的分化和移植。
Stem Cell Res Ther. 2018 Aug 29;9(1):230. doi: 10.1186/s13287-018-0967-1.

引用本文的文献

1
Termination sequence between an inducible promoter and ubiquitous chromatin opening element (UCOE) reduces gene expression leakage and silencing.诱导型启动子与泛在染色质开放元件(UCOE)之间的终止序列可减少基因表达泄漏和沉默。
J Biol Eng. 2025 Apr 9;19(1):29. doi: 10.1186/s13036-025-00499-8.
2
Directed differentiation of human embryonic stem cells into parathyroid cells and establishment of parathyroid organoids.人胚胎干细胞的定向分化为甲状旁腺细胞和甲状旁腺类器官的建立。
Cell Prolif. 2024 Aug;57(8):e13634. doi: 10.1111/cpr.13634. Epub 2024 Mar 18.
3
Generation of functional thymic organoids from human pluripotent stem cells.
从人类多能干细胞生成功能性胸腺类器官。
Stem Cell Reports. 2023 Apr 11;18(4):829-840. doi: 10.1016/j.stemcr.2023.02.013. Epub 2023 Mar 23.
4
Congenital Athymia: Unmet Needs and Practical Guidance.先天性无胸腺症:未满足的需求与实用指南。
Ther Clin Risk Manag. 2023 Mar 13;19:239-254. doi: 10.2147/TCRM.S379673. eCollection 2023.
5
Cellular rejuvenation: molecular mechanisms and potential therapeutic interventions for diseases.细胞衰老的研究:疾病的分子机制和潜在的治疗干预措施。
Signal Transduct Target Ther. 2023 Mar 14;8(1):116. doi: 10.1038/s41392-023-01343-5.
6
Human thymus in health and disease: Recent advances in diagnosis and biology.健康与疾病中的人类胸腺:诊断和生物学的最新进展。
Semin Immunol. 2023 Mar;66:101732. doi: 10.1016/j.smim.2023.101732. Epub 2023 Feb 28.
7
De novo construction of T cell compartment in humanized mice engrafted with iPSC-derived thymus organoids.人源化小鼠嵌合体中 iPSC 衍生胸腺类器官中 T 细胞区室的从头构建。
Nat Methods. 2022 Oct;19(10):1306-1319. doi: 10.1038/s41592-022-01583-3. Epub 2022 Sep 5.
8
Differentiation of Pluripotent Stem Cells Into Thymic Epithelial Cells and Generation of Thymic Organoids: Applications for Therapeutic Strategies Against APECED.多能干细胞向胸腺上皮细胞的分化及胸腺类器官的生成:针对自身免疫性多内分泌腺病-念珠菌病-外胚层营养不良治疗策略的应用
Front Immunol. 2022 Jun 29;13:930963. doi: 10.3389/fimmu.2022.930963. eCollection 2022.
9
Stem Cell-Based Disease Models for Inborn Errors of Immunity.基于干细胞的先天性免疫缺陷疾病模型。
Cells. 2021 Dec 30;11(1):108. doi: 10.3390/cells11010108.
10
Modeling human T1D-associated autoimmune processes.模拟人类 T1D 相关的自身免疫过程。
Mol Metab. 2022 Feb;56:101417. doi: 10.1016/j.molmet.2021.101417. Epub 2021 Dec 10.