Epstein S W, Vanderlinden R G, Man S F, Hyland R H, Lenkei S C, Wise D J, Meindok H
Can Med Assoc J. 1979 Jun 9;120(11):1360-8.
Electric stimulation of the diaphragm via the phrenic nerve to induce ventilation has recently been used for the long-term management of chronic ventilatory insufficiency. Since 1973 three patients with inadequate alveolar ventilation have been treated with diaphragm pacing at the Toronto Western Hospital. Two, who had quadriplegia due to lesions of the spinal cord in the upper cervical region and a severe restrictive ventilatory defect, were treated with continuous diaphragm pacing. The third patient required assisted nocturnal ventilation because of primary alveolar hypoventilation. All three patients tolerated the diaphragm pacing well, and pulmonary function tests showed satisfactory gas exchange with the patients breathing room air. This form of therapy seems to be a practical clinical method of managing chronic ventilatory failure in patients with lesions of the upper cervical cord or primary alveolar hypoventilation.
通过膈神经对膈肌进行电刺激以诱导通气，最近已被用于慢性通气功能不全的长期管理。自1973年以来，多伦多西部医院已有三名肺泡通气不足的患者接受了膈肌起搏治疗。其中两名患者因上颈段脊髓损伤导致四肢瘫痪，并伴有严重的限制性通气缺陷，接受了持续的膈肌起搏治疗。第三名患者因原发性肺泡通气不足需要夜间辅助通气。所有三名患者对膈肌起搏的耐受性良好，肺功能测试显示患者在呼吸室内空气时气体交换情况令人满意。这种治疗方式似乎是管理上颈段脊髓损伤或原发性肺泡通气不足患者慢性通气衰竭的一种实用临床方法。
