玛丽洛糖苷 A-G，来自大花玛丽Laurencin 叶的诺环烷糖苷

Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-Cho, Tokushima 770-8514, Japan.

Kawano-Mericlone Co. Ltd., Wakimachi, Tokushima 779-3604, Japan.

Molecules. 2019 Jul 9;24(13):2504. doi: 10.3390/molecules24132504.

Seven novel norcycloartane glycosides, maryloside A-G (-), were isolated from the leaves of Great Flower 'Marylaurencin', along with a known norcycloartane glycoside, cymbidoside (). These structures were determined on the basis of mainly NMR experiments as well as chemical degradation and X-ray crystallographic analysis. The isolated compounds (- and ) were evaluated for the inhibitory activity on lipopolysaccharide (LPS) and interferon-γ (IFN-γ)-stimulated nitric oxide (NO) production in RAW 264.7 cells. Consequently, and exhibited moderate activity.

从大花玛丽Laurencin 的叶子中分离得到了 7 种新型的诺卡烷糖苷，玛丽洛苷 A-G（-），以及一种已知的诺卡烷糖苷，环宝素苷（）。这些结构主要基于 NMR 实验以及化学降解和 X 射线晶体学分析确定。对分离得到的化合物（- 和）进行了 LPS 和 IFN-γ 刺激的 RAW 264.7 细胞中 NO 产生抑制活性的评价。结果表明，和具有中等活性。